11-beta-hydroxysteroid dehydrogenase (NAD+) activity

Definition

Target type: molecularfunction

Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+. [PMID:15761036, RHEA:53116]

11-beta-hydroxysteroid dehydrogenase (NAD+) activity catalyzes the interconversion of cortisol and cortisone. This enzymatic activity is critical for maintaining the hormonal balance of glucocorticoids in the body. Cortisol, the active form of the hormone, is required for a range of physiological processes, including stress response, metabolism, and immune function. Cortisone, on the other hand, is inactive. 11-beta-hydroxysteroid dehydrogenase (NAD+) activity plays a crucial role in regulating the concentration of active cortisol in target tissues by converting cortisone to cortisol in tissues with high NAD+ levels, such as the liver and adrenal glands. Conversely, in tissues with low NAD+ levels, like the kidney and brain, it converts cortisol to cortisone. This enzymatic activity ensures that cortisol is readily available in tissues that require it and minimizes its activity in tissues that are sensitive to its effects. The enzyme uses NAD+ as a cofactor and requires the presence of nicotinamide adenine dinucleotide (NAD+) for its function. Mutations in the gene encoding 11-beta-hydroxysteroid dehydrogenase (NAD+) can lead to various health conditions, including hypertension, metabolic syndrome, and Cushing's syndrome.'
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Proteins (1)

Compounds (12)