Target type: molecularfunction
Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis. [GOC:BHF, GOC:hal]
Folic acid receptor activity is a molecular function involved in the binding and transport of folate, an essential vitamin required for various metabolic processes. Folate receptors are transmembrane proteins located on the cell surface that specifically bind to folic acid. This binding event triggers the internalization of folate into the cell via endocytosis. Once inside the cell, folate is converted into tetrahydrofolic acid (THF), which acts as a coenzyme for several key enzymes involved in DNA synthesis, repair, and methylation. These processes are essential for cell growth, division, and normal function. Folic acid receptor activity is therefore crucial for maintaining cellular homeostasis and proper development. Defects in folic acid receptor activity can lead to folate deficiency, a condition that can cause various health issues, including megaloblastic anemia, neural tube defects, and cardiovascular disease.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Folate receptor alpha | A folate receptor alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P15328] | Homo sapiens (human) |
| Folate receptor beta | A folate receptor beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14207] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| methotrexate | dicarboxylic acid; monocarboxylic acid amide; pteridines | abortifacient; antimetabolite; antineoplastic agent; antirheumatic drug; dermatologic drug; DNA synthesis inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; immunosuppressive agent | |
| 10-propargyl-10-deazaaminopterin | 10-propargyl-10-deazaaminopterin: structure in first source pralatrexate : A pteridine that is the N-4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl derivative of L-glutamic acid. Used for treatment of Peripheral T-Cell Lymphoma, an aggressive form of non-Hodgkins lymphoma. | N-acyl-L-glutamic acid; pteridines; terminal acetylenic compound | antimetabolite; antineoplastic agent; EC 1.5.1.3 (dihydrofolate reductase) inhibitor |
| raltitrexed | N-acyl-amino acid | ||
| pemetrexed | pemetrexed disodium : An organic sodium salt that is the disodium salt of N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). | N-acyl-L-glutamic acid; pyrrolopyrimidine | antimetabolite; antineoplastic agent; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; EC 2.1.1.45 (thymidylate synthase) inhibitor; EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor |