endopeptidase regulator activity
Definition
Target type: molecularfunction
Binds to and modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. [GOC:dph, GOC:tb]
Endopeptidase regulator activity is a molecular function associated with proteins that control the activity of endopeptidases. Endopeptidases are enzymes that cleave peptide bonds within a polypeptide chain, breaking down proteins into smaller peptides. Endopeptidase regulators can modulate the activity of these enzymes in various ways, including:
* **Activation:** Some regulators can activate endopeptidases by promoting their conformational changes, binding to and stabilizing their active state, or removing inhibitory factors.
* **Inhibition:** Other regulators can inhibit endopeptidases by binding to their active site, blocking substrate access, or inducing conformational changes that deactivate the enzyme.
* **Modulation:** Some regulators can fine-tune the activity of endopeptidases by altering their substrate specificity, affinity, or catalytic efficiency.
The specific mechanism of regulation can vary depending on the regulator and the endopeptidase it interacts with. For instance, some regulators may act as cofactors, providing essential components for the enzyme's catalytic activity. Others may be involved in the trafficking, localization, or degradation of endopeptidases, indirectly controlling their activity.
Endopeptidase regulator activity plays a crucial role in diverse biological processes, including:
* **Protein degradation:** Regulating endopeptidase activity is essential for protein turnover, a fundamental process in cells that involves the breakdown and recycling of proteins.
* **Signal transduction:** Some endopeptidases are involved in signal transduction pathways, where they cleave specific proteins to activate or inactivate signaling molecules.
* **Immune response:** Endopeptidases and their regulators play roles in the immune system, including the processing of antigens and the activation of immune cells.
* **Development and differentiation:** Endopeptidase activity is important for cell growth, differentiation, and development.
Defects in endopeptidase regulator activity can lead to various pathological conditions, including genetic disorders, developmental abnormalities, and diseases related to protein misfolding and degradation.'
"
Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| E3 ubiquitin-protein ligase XIAP | A baculoviral IAP repeat-containing protein 4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P98170] | Homo sapiens (human) |
Compounds (12)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| embelin | embelin : A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, antineoplastic and inhibitory activity towards hepatitis C protease. embelin: from Embelia fruit (Myrsinaceae) | dihydroxy-1,4-benzoquinones | antimicrobial agent; antineoplastic agent; hepatitis C protease inhibitor; plant metabolite |
| phenylalanine | L-phenylalanine : The L-enantiomer of phenylalanine. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group. Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE. | amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid | algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite |
| kaempferol | 7-hydroxyflavonol; flavonols; tetrahydroxyflavone | antibacterial agent; geroprotector; human blood serum metabolite; human urinary metabolite; human xenobiotic metabolite; plant metabolite | |
| kaempferol 3-o-rhamnoside | afzelin : A glycosyloxyflavone that is kaempferol attached to an alpha-L-rhamnosyl residue at position 3 via a glycosidic linkage. kaempferol 3-O-rhamnoside: from apple (Malus domestica) leaves; structure in first source | glycosyloxyflavone; monosaccharide derivative; trihydroxyflavone | anti-inflammatory agent; antibacterial agent; plant metabolite |
| lbw242 | LBW242: proapoptotic IAP inhibitor; low MW Smac (Second mitochondria-derived activator of caspases) mimetic; structure in first source | ||
| sm 164 | SM 164: a bivalent Smac mimetic with antineoplastic activity; structure in first source | benzenes; organic heterobicyclic compound; secondary carboxamide; triazoles | antineoplastic agent; apoptosis inducer; radiosensitizing agent |
| lcl161 | 1,3-thiazoles; aromatic ketone; L-alanine derivative; monofluorobenzenes; N-acylpyrrolidine | antineoplastic agent; apoptosis inducer | |
| at 406 | |||
| gdc-0152 | GDC-0152: structure in first source | ||
| birinapant | birinapant: a Smac mimetic with antineoplastic activity | dipeptide | |
| nvp-cgm097 | NVP-CGM097: an MDM2 and HDM2 inhibitor; structure in first source | ||
| 2-carboxyarabinitol 1-phosphate |