Page last updated: 2024-10-24

N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity

Definition

Target type: molecularfunction

Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide. [MetaCyc:POLYAMINE-OXIDASE-RXN]

N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity catalyzes the oxidation of N1-acetylspermine, a polyamine, using molecular oxygen as the electron acceptor. This reaction results in the formation of N1-acetylspermidine, another polyamine, and hydrogen peroxide. The enzyme is involved in the biosynthesis of polyamines, which are essential for various cellular processes, including cell growth, differentiation, and proliferation. The specific role of this enzyme in polyamine metabolism and its implications for cellular function are still being investigated. The enzyme likely plays a role in regulating the levels of polyamines in cells, which can impact cell growth and proliferation. Further research is needed to fully elucidate its role in cellular processes.'
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Proteins (1)

ProteinDefinitionTaxonomy
Spermine oxidaseA spermine oxidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NWM0]Homo sapiens (human)

Compounds (3)

CompoundDefinitionClassesRoles
N5-(2-chloro-6-phenoxybenzyl)-1H-1,2,4-triazole-3,5-diaminearomatic ether
mdl 72527MDL 72527: RN given refers to di-HCl; RN for parent cpd not available 6/85; polyamine oxidase inhibitor
chlorhexidinechlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.

Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.
biguanides;
monochlorobenzenes
antibacterial agent;
antiinfective agent