Target type: molecularfunction
Catalysis of the reaction: norspermine + oxygen + H2O = norspermidine + 3-aminopropanal + hydrogen peroxide. [MetaCyc:RXN-10464]
Norspermine:oxygen oxidoreductase activity catalyzes the oxidation of norspermine, a polyamine compound, using molecular oxygen as the electron acceptor. The enzyme typically belongs to the amine oxidase family and employs a flavin adenine dinucleotide (FAD) cofactor for catalysis. The reaction mechanism involves the formation of a covalent intermediate between the substrate (norspermine) and the enzyme, followed by the transfer of electrons from the substrate to FAD, resulting in the production of hydrogen peroxide and the oxidized form of norspermine. This enzymatic activity plays a crucial role in the metabolism of polyamines, which are involved in various cellular processes, including cell growth, proliferation, and differentiation. The specific biological function of norspermine:oxygen oxidoreductase activity may vary depending on the organism and the cellular context. Some studies suggest that this enzyme is involved in the detoxification of reactive oxygen species and the regulation of polyamine homeostasis. However, further research is needed to fully elucidate its physiological role.'
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Protein | Definition | Taxonomy |
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Spermine oxidase | A spermine oxidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NWM0] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
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N5-(2-chloro-6-phenoxybenzyl)-1H-1,2,4-triazole-3,5-diamine | aromatic ether | ||
mdl 72527 | MDL 72527: RN given refers to di-HCl; RN for parent cpd not available 6/85; polyamine oxidase inhibitor | ||
chlorhexidine | chlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge. Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. | biguanides; monochlorobenzenes | antibacterial agent; antiinfective agent |