Target type: molecularfunction
Catalysis of the reaction: FMNH2 + NAD+ = FMN + NADH + 2 H+. [RHEA:21620]
FMN reductase (NADH) activity catalyzes the transfer of electrons from NADH to flavin mononucleotide (FMN), reducing FMN to FMNH2. This reaction is essential for various metabolic pathways, including the biosynthesis of nucleotides, fatty acids, and amino acids, as well as the detoxification of reactive oxygen species. The enzyme utilizes NADH as an electron donor and FMN as an electron acceptor, facilitating the transfer of reducing equivalents from NADH to FMN. The reduced form of FMN, FMNH2, serves as a crucial cofactor in various enzymatic reactions, such as those catalyzed by flavoproteins. FMN reductases are widely distributed in organisms, playing a vital role in cellular respiration, oxidative stress management, and the production of essential biomolecules. The specific molecular function of FMN reductase (NADH) activity involves the formation of a transient enzyme-substrate complex, where NADH binds to the active site and donates electrons to the FMN cofactor. This process involves a series of conformational changes and redox reactions, ultimately leading to the reduction of FMN and the regeneration of NAD+. The enzyme's efficiency is influenced by factors such as pH, temperature, and the presence of inhibitors or activators. The precise mechanism and kinetics of FMN reductase (NADH) activity may vary depending on the specific enzyme and its cellular context. However, the core function remains consistent, which is the transfer of reducing equivalents from NADH to FMN, contributing to a wide range of metabolic processes.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Flavin reductase (NADPH) | A flavin reductase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30043] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| erythrosine | Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays. | ||
| sulfasalazine | sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position. Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907) | ||
| olsalazine | olsalazine : An azobenzene that consists of two molecules of 4-aminosalicylic acid joined by an azo linkage. A prodrug for mesalazine, an anti-inflammatory drug, it is used (as the disodium salt) in the treatment of inflammatory bowel disease. olsalazine: cpd with 2 salicylate molecules linked together by an azo bond | azobenzenes; dicarboxylic acid | non-steroidal anti-inflammatory drug; prodrug |
| tamibarotene | tamibarotene : A dicarboxylic acid monoamide resulting from the condensation of one of the carboxy groups of terephthalic acid with the amino group of 5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-amine. tamibarotene: has retinoid-binding activity | dicarboxylic acid monoamide; retinoid; tetralins | antineoplastic agent; retinoic acid receptor alpha/beta agonist |
| febuxostat | febuxostat : A 1,3-thiazolemonocarboxylic acid that is 4-methyl-1,3-thiazole-5-carboxylic acid which is substituted by a 3-cyano-4-(2-methylpropoxy)phenyl group at position 2. It is an orally-active, potent, and selective xanthine oxidase inhibitor used for the treatment of chronic hyperuricaemia in patients with gout. Febuxostat: A thiazole derivative and inhibitor of XANTHINE OXIDASE that is used for the treatment of HYPERURICEMIA in patients with chronic GOUT. | 1,3-thiazolemonocarboxylic acid; aromatic ether; nitrile | EC 1.17.3.2 (xanthine oxidase) inhibitor |
| deferasirox | deferasirox : A member of the class of triazoles, deferasirox is 1,2,4-triazole substituted by a 4-carboxyphenyl group at position 1 and by 2-hydroxyphenyl groups at positions 3 and 5. An orally active iron chelator, it is used to manage chronic iron overload in patients receiving long-term blood transfusions. Deferasirox: A triazole and benzoate derivative that acts as a selective iron chelator. It is used in the management of chronic IRON OVERLOAD due to blood transfusion or non-transfusion dependent THALASSEMIA. | benzoic acids; monocarboxylic acid; phenols; triazoles | iron chelator |
| ptc 124 | oxadiazole; ring assembly |