Target type: molecularfunction
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+. [PMID:19901554, RHEA:39019]
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity catalyzes the hydrolysis of the phosphate group at the 3-position of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). This reaction converts PtdIns(3,5)P2 to phosphatidylinositol-5-phosphate (PtdIns(5)P), a key signaling molecule involved in various cellular processes. The phosphatase activity is critical for maintaining the appropriate levels of PtdIns(3,5)P2, which is a crucial regulator of membrane trafficking, cytoskeletal organization, and cell growth. The enzyme's activity is often tightly regulated by various cellular factors, such as phosphorylation, protein-protein interactions, and changes in intracellular calcium concentration. Disruptions in phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity can lead to various cellular malfunctions and contribute to the development of diseases.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Synaptojanin-1 | A synaptojanin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43426] | Homo sapiens (human) |
| Synaptojanin-2 | A synaptojanin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15056] | Homo sapiens (human) |
| Synaptojanin-1 | A synaptojanin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43426] | Homo sapiens (human) |
| Synaptojanin-2 | A synaptojanin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15056] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| epicatechin gallate | (-)-epicatechin-3-O-gallate : A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of epicatechin. A natural product found in Parapiptadenia rigida. epicatechin gallate: a steroid 5alpha-reductase inhibitor; RN given refers to the (cis)-isomer; structure given in first source; isolated from green tea | catechin; gallate ester; polyphenol | EC 3.2.1.1 (alpha-amylase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; metabolite |
| ampelopsin | (+)-dihydromyricetin : An optically active form of dihydromyricetin having (2R,3R)-configuration. ampelopsin: hepatoprotective agent; isolated from Hovenia dulcis; RN given for (2R-trans)-isomer; structure in first source | dihydromyricetin; secondary alpha-hydroxy ketone | antineoplastic agent; antioxidant; metabolite |
| epiafzelechin | (-)-epiafzelechin : A catechin derivative having (2R,3R)-configuration. epiafzelechin: antioxidant; 3'-deoxy form of epicatechin; structure in first source | catechin | plant metabolite |
| pyrvinium | pyrvinium : A quinolinium ion that is 1-methylquinolinium substituted by dimethylamino group at position 6 and a (E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl at position 2. It is a anthelminthic drug active against pinworms. The salts of pyrvinium can also be used as anticancer agents. pyrvinium: RN given refers to parent cpd; synonyms vanquin & vankin refer to pamoate[2:1]; structure in Merck Index, 9th ed, #7810 | quinolinium ion | anthelminthic drug; antineoplastic agent |
| trans-2,3',4,5'-tetrahydroxystilbene | trans-2,3',4,5'-tetrahydroxystilbene: hydroxystilbene oxyresveratrol | stilbenoid | |
| chlorhexidine | chlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge. Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. | biguanides; monochlorobenzenes | antibacterial agent; antiinfective agent |
| eriodictyol 7-O-beta-D-glucopyranoside | beta-D-glucoside; flavanone glycoside; monosaccharide derivative; trihydroxyflavanone | plant metabolite; radical scavenger |