Target type: molecularfunction
Catalysis of the reaction: propane-1,3-diamine + H2O + O2 = 3-aminopropanal + NH3 + hydrogen peroxide + H+. [MetaCyc:RXN-6381]
Propane-1,3-diamine oxidase (EC 1.4.3.22) is an enzyme that catalyzes the oxidative deamination of primary amines, specifically propane-1,3-diamine. This reaction involves the removal of an amino group (-NH2) from the substrate, yielding the corresponding aldehyde, ammonia (NH3), and hydrogen peroxide (H2O2). The enzyme is a flavoenzyme, meaning it utilizes flavin adenine dinucleotide (FAD) as a cofactor. The catalytic cycle begins with the binding of propane-1,3-diamine to the enzyme's active site. The FAD cofactor then oxidizes the amine substrate, producing an imine intermediate. This intermediate is subsequently hydrolyzed, releasing the aldehyde product and ammonia. The reduced FAD cofactor is then reoxidized by molecular oxygen, producing hydrogen peroxide as a byproduct. This reaction is essential for the metabolism of diamines in various organisms, including bacteria, fungi, and mammals. Propane-1,3-diamine oxidase plays a crucial role in the detoxification of diamines, which can be toxic to cells. It is also involved in the biosynthesis of certain signaling molecules, such as histamine.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Amiloride-sensitive amine oxidase [copper-containing] | An amiloride-sensitive amine oxidase [copper-containing] that is encoded in the genome of human. [PRO:DNx, UniProtKB:P19801] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| diminazene | diminazene : A triazene derivative that is triazene in which each of the terminal nitrogens is substituted by a 4-carbamimidoylphenyl group. Diminazene: An effective trypanocidal agent. | carboxamidine; triazene derivative | antiparasitic agent; trypanocidal drug |
| pentamidine | pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease. Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | aromatic ether; carboxamidine; diether | anti-inflammatory agent; antifungal agent; calmodulin antagonist; chemokine receptor 5 antagonist; EC 2.3.1.48 (histone acetyltransferase) inhibitor; NMDA receptor antagonist; S100 calcium-binding protein B inhibitor; trypanocidal drug; xenobiotic |
| benzylamine | aminotoluene : Any member of the class of toluenes carrying one or more amino groups. | aralkylamine; primary amine | allergen; EC 3.5.5.1 (nitrilase) inhibitor; plant metabolite |