Target type: molecularfunction
Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2. [EC:1.4.3.10, MetaCyc:PUTRESCINE-OXIDASE-RXN]
Putrescine oxidase activity is a critical enzyme involved in the catabolism of polyamines, particularly putrescine. It catalyzes the oxidation of putrescine to 4-aminobutanal, a key step in the biosynthesis of γ-aminobutyric acid (GABA), an important neurotransmitter. The reaction involves the transfer of two electrons from putrescine to molecular oxygen, producing hydrogen peroxide as a byproduct. Putrescine oxidase belongs to the flavin-containing amine oxidase family and utilizes flavin adenine dinucleotide (FAD) as a cofactor. The enzyme typically exhibits substrate specificity for putrescine and related diamines, displaying varying degrees of activity towards other polyamines. Putrescine oxidase plays a crucial role in maintaining cellular polyamine homeostasis, which is essential for normal cell growth, proliferation, and differentiation. Dysregulation of putrescine oxidase activity has been implicated in various pathological conditions, including cancer, inflammation, and neurodegenerative disorders. The enzyme is also of significant interest as a potential therapeutic target for these conditions.'
"
| Protein | Definition | Taxonomy |
|---|---|---|
| Amiloride-sensitive amine oxidase [copper-containing] | An amiloride-sensitive amine oxidase [copper-containing] that is encoded in the genome of human. [PRO:DNx, UniProtKB:P19801] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| diminazene | diminazene : A triazene derivative that is triazene in which each of the terminal nitrogens is substituted by a 4-carbamimidoylphenyl group. Diminazene: An effective trypanocidal agent. | carboxamidine; triazene derivative | antiparasitic agent; trypanocidal drug |
| pentamidine | pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease. Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | aromatic ether; carboxamidine; diether | anti-inflammatory agent; antifungal agent; calmodulin antagonist; chemokine receptor 5 antagonist; EC 2.3.1.48 (histone acetyltransferase) inhibitor; NMDA receptor antagonist; S100 calcium-binding protein B inhibitor; trypanocidal drug; xenobiotic |
| benzylamine | aminotoluene : Any member of the class of toluenes carrying one or more amino groups. | aralkylamine; primary amine | allergen; EC 3.5.5.1 (nitrilase) inhibitor; plant metabolite |