Page last updated: 2024-10-24

ubiquinone binding

Definition

Target type: molecularfunction

Binding to ubiquinone, a quinone derivative with a tail of isoprene units. [GOC:jid, ISBN:0582227089]

Ubiquinone binding is a molecular function that describes the interaction of a protein with ubiquinone, also known as coenzyme Q10. Ubiquinone is a small, lipid-soluble molecule that plays a crucial role in cellular respiration, specifically in the electron transport chain. It acts as a mobile electron carrier, shuttling electrons between protein complexes in the mitochondrial membrane.

In the electron transport chain, ubiquinone accepts electrons from complex I and II, becoming reduced to ubiquinol (QH2). This reduced form then carries the electrons to complex III, where it is oxidized back to ubiquinone. This cycle of oxidation and reduction allows for the transfer of electrons from NADH and FADH2 to molecular oxygen, ultimately generating a proton gradient across the mitochondrial membrane that drives ATP synthesis.

Ubiquinone binding proteins are typically transmembrane proteins, often embedded within the mitochondrial membrane. They contain specific binding sites for ubiquinone, which can vary in their affinity and specificity. These binding sites are often characterized by hydrophobic residues that interact with the hydrophobic tail of ubiquinone, and polar residues that interact with the quinone head group.

The binding of ubiquinone to these proteins is essential for the proper functioning of the electron transport chain. Mutations or defects in ubiquinone binding proteins can lead to mitochondrial dysfunction and a range of diseases, including mitochondrial encephalomyopathies.'
"

Proteins (1)

ProteinDefinitionTaxonomy
NADH-ubiquinone oxidoreductase chain 4An NADH-ubiquinone oxidoreductase chain 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P03905]Homo sapiens (human)

Compounds (3)

CompoundDefinitionClassesRoles
daunorubicinanthracycline : Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.

daunorubicin : A natural product found in Actinomadura roseola.

Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.
aminoglycoside antibiotic;
anthracycline;
p-quinones;
tetracenequinones
antineoplastic agent;
bacterial metabolite
auraptenaurapten: RN refers to (E)-isomer; structure given in first source

auraptene : A member of the class of coumarins that is umbelliferone in which the phenolic hydrogen has been replaced by a geranyl group. Ii is isolated from several edible fruits and vegetables and exhibits a variety of therapeutic properties.
coumarins;
monoterpenoid
antihypertensive agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
dopaminergic agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
gamma-secretase modulator;
gastrointestinal drug;
hepatoprotective agent;
matrix metalloproteinase inhibitor;
neuroprotective agent;
plant metabolite;
PPARalpha agonist;
vulnerary
marminmarmin: structure in first source; RN given for (R-(E))-isomer