Target type: molecularfunction
Catalysis of the reaction: S-substituted L-cysteine + H2O = a thiol + NH4+ + pyruvate. [RHEA:18121]
Cysteine-S-conjugate beta-lyase activity is a crucial enzyme activity involved in the detoxification of a wide range of electrophilic compounds, including xenobiotics, drugs, and environmental toxins. These compounds can undergo conjugation reactions with glutathione, a tripeptide, to form cysteine-S-conjugates. Cysteine-S-conjugate beta-lyase catalyzes the beta-elimination of these cysteine-S-conjugates, cleaving the carbon-sulfur bond and releasing a thiol, a reactive compound, and a pyruvate molecule. The thiol generated can then be further metabolized, facilitating its excretion from the body. This process is vital for protecting cells from the damaging effects of electrophilic compounds, which can cause oxidative stress, DNA damage, and protein modifications. The enzyme plays a significant role in the detoxification of various compounds, including reactive oxygen species, heavy metals, and environmental pollutants. Moreover, cysteine-S-conjugate beta-lyase activity has been implicated in the pathogenesis of certain diseases, such as drug-induced liver injury, cancer, and cardiovascular disease.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Cystathionine beta-lyase MetC | A cystathionine beta-lyase MetC that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P06721] | Escherichia coli K-12 |
| Kynurenine--oxoglutarate transaminase 3 | A kynurenine--oxoglutarate transaminase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6YP21] | Homo sapiens (human) |
| Kynurenine--oxoglutarate transaminase 1 | A kynurenine--oxoglutarate transaminase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16773] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| indolepropionic acid | 3-(1H-indol-3-yl)propanoic acid : An indol-3-yl carboxylic acid that is propionic acid substituted by a 1H-indol-3-yl group at position 3. indolepropionic acid: structure in third source | indol-3-yl carboxylic acid | auxin; human metabolite; plant metabolite |
| 4-toluenesulfonyl hydrazide | |||
| indole-3-lactic acid | 3-(indol-3-yl)lactic acid : A hydroxy monocarboxylic acid that is lactic acid substituted by a 1H-indol-3-yl group at position 3. It is a metabolite of tryptophan. indole-3-lactic acid: RN given refers to cpd without isomeric designation | hydroxy monocarboxylic acid; indol-3-yl carboxylic acid | human metabolite |
| pf-04859989 | PF-04859989: a potent, brain-penetrant inhibitor of kynurenine aminotransferase II/KAT II with in vivo activity; structure in first source |