C-C motif chemokine 21 receptor activity

Definition

Target type: molecularfunction

Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:signaling, PMID:15059845]

C-C motif chemokine 21 receptor activity is a molecular function that describes the ability of a protein to bind and respond to the chemokine CCL21. CCL21 is a small, secreted protein that plays a crucial role in the immune system by attracting and activating immune cells, particularly lymphocytes.

The CCL21 receptor, known as CCR7, is a G protein-coupled receptor (GPCR) expressed on the surface of lymphocytes, dendritic cells, and other immune cells. When CCL21 binds to CCR7, it triggers a signaling cascade within the cell. This cascade involves the activation of intracellular signaling pathways, such as the MAPK and PI3K pathways, which ultimately lead to changes in cell behavior.

These changes can include:

* **Chemotaxis:** CCL21 acts as a chemoattractant, guiding lymphocytes and dendritic cells towards areas of inflammation or infection.
* **Cell migration:** CCL21 promotes the migration of immune cells to specific locations within the body, such as lymph nodes.
* **Cell activation:** CCL21 can activate lymphocytes, leading to the production of cytokines and other immune mediators.
* **Lymphocyte homing:** CCL21 plays a crucial role in directing lymphocytes to specific compartments within lymphoid tissues, such as the lymph nodes and spleen.

CCR7 signaling is essential for the proper development and function of the immune system. Dysregulation of CCR7 signaling has been implicated in various diseases, including cancer, autoimmune disorders, and infectious diseases.'
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Proteins (1)

Compounds (2)