5-hydroxy-L-tryptophan decarboxylase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin. [GOC:bf, GOC:PARL, RHEA:18533]
5-Hydroxy-L-tryptophan decarboxylase activity catalyzes the conversion of 5-hydroxy-L-tryptophan (5-HTP) to serotonin (5-HT). This reaction involves the removal of a carboxyl group from 5-HTP, resulting in the formation of serotonin. The decarboxylation reaction requires the cofactor pyridoxal phosphate (PLP), which is a derivative of vitamin B6. 5-Hydroxy-L-tryptophan decarboxylase is a key enzyme in the biosynthesis of serotonin, a neurotransmitter that plays a vital role in regulating mood, sleep, appetite, and other physiological functions. The enzyme is highly specific for 5-HTP, and its activity is tightly regulated to ensure the proper balance of serotonin levels in the brain and other tissues. 5-Hydroxy-L-tryptophan decarboxylase activity is crucial for maintaining normal brain function and for responding to various physiological and environmental cues.'
"
Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Aromatic-L-amino-acid decarboxylase | An aromatic-L-amino-acid decarboxylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20711] | Homo sapiens (human) |
Compounds (4)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| chelerythrine | chelerythrine : A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae. | benzophenanthridine alkaloid; organic cation | antibacterial agent; antineoplastic agent; EC 2.7.11.13 (protein kinase C) inhibitor |
| nitidine | nitidine: RN given refers to parent cpd; synonym NSC 146397 refers to chloride; structure | phenanthridines | |
| piritrexim | piritrexim: RN given refers to parent cpd; structure given in first source | ||
| sanguinarine chloride |