5-hydroxy-L-tryptophan decarboxylase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin. [GOC:bf, GOC:PARL, RHEA:18533]

5-Hydroxy-L-tryptophan decarboxylase activity catalyzes the conversion of 5-hydroxy-L-tryptophan (5-HTP) to serotonin (5-HT). This reaction involves the removal of a carboxyl group from 5-HTP, resulting in the formation of serotonin. The decarboxylation reaction requires the cofactor pyridoxal phosphate (PLP), which is a derivative of vitamin B6. 5-Hydroxy-L-tryptophan decarboxylase is a key enzyme in the biosynthesis of serotonin, a neurotransmitter that plays a vital role in regulating mood, sleep, appetite, and other physiological functions. The enzyme is highly specific for 5-HTP, and its activity is tightly regulated to ensure the proper balance of serotonin levels in the brain and other tissues. 5-Hydroxy-L-tryptophan decarboxylase activity is crucial for maintaining normal brain function and for responding to various physiological and environmental cues.'
"

Proteins (1)

Compounds (4)