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UTP diphosphatase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: UTP + H2O = UMP + H+ + diphosphate. [GOC:dgf, PMID:17899088, RHEA:29395]

UTP diphosphatase activity refers to the enzymatic hydrolysis of uridine triphosphate (UTP) into uridine monophosphate (UMP) and pyrophosphate (PPi). This reaction is catalyzed by enzymes known as UTP diphosphatases. The molecular function of this activity can be described as follows:

1. **Hydrolysis of UTP:** UTP diphosphatases cleave the phosphoanhydride bond between the beta and gamma phosphate groups of UTP, releasing inorganic pyrophosphate (PPi).

2. **Regulation of UTP levels:** This enzymatic activity plays a crucial role in regulating cellular levels of UTP. By hydrolyzing UTP, UTP diphosphatases reduce the concentration of this nucleotide, which can affect various cellular processes, including nucleotide metabolism, signal transduction, and gene expression.

3. **Energy metabolism:** The hydrolysis of UTP releases energy, which can be utilized by cells for various metabolic processes.

4. **Nucleotide synthesis:** UTP diphosphatases can contribute to the synthesis of other nucleotides, such as UMP, which is a precursor for the synthesis of other pyrimidine nucleotides.

5. **Cellular signaling:** UTP diphosphatases can be involved in cellular signaling pathways by regulating the levels of UTP, which can act as a signaling molecule in certain cellular processes.

6. **Cellular differentiation and development:** UTP diphosphatases have been implicated in cellular differentiation and development, although the precise mechanisms involved are not fully understood.

7. **Enzyme activity:** UTP diphosphatase activity is often associated with specific enzymes, such as nucleoside diphosphate kinases (NDKs), which can catalyze the transfer of a phosphate group from ATP to UTP, generating UTP from UDP.'
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Proteins (1)

ProteinDefinitionTaxonomy
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1An ectonucleotide pyrophosphatase/phosphodiesterase family member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22413]Homo sapiens (human)

Compounds (8)

CompoundDefinitionClassesRoles
alpha,beta-methyleneadenosine 5'-triphosphatealpha,beta-methyleneadenosine 5'-triphosphate: do not confuse with beta,gamma-methylene ATP; RN given refers to parent cpdnucleoside triphosphate analogue
adenosine 5'-methylenediphosphatenucleoside diphosphate analogue
3'-o-(4-benzoyl)benzoyladenosine 5'-triphosphate3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate: purinergic receptors agonist; structure given in first sourcepurine ribonucleoside triphosphate
methylthio-adp
Reactive blue 2anthraquinone
2-methylthio-atp2-methylthio-ATP: purinergic receptors agonist; relaxes mammalian gut preparations; structure given in first source
adenosine 5'-diphosphate 2',3'-dialdehyde
arl-671566-N,N-diethyl-beta,gamma-dibromomethylene-D-ATP: an inhibitor of ecto-ATPase