Target type: molecularfunction
Binding to chemokine (C-C motif) ligand 21. [GOC:BHF]
Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine that plays a critical role in the immune system by mediating the recruitment and trafficking of immune cells, particularly lymphocytes, to specific locations within the body. CCL21 binds to its receptors, CCR7 and CCR9, which are expressed on the surface of lymphocytes. This binding triggers a cascade of intracellular signaling events that ultimately lead to the migration of lymphocytes towards the source of CCL21. CCL21 is a potent chemoattractant for both naive and memory T cells, as well as for dendritic cells, which are antigen-presenting cells. It is produced by a variety of cells, including stromal cells, epithelial cells, and macrophages. CCL21 is found in secondary lymphoid organs, such as lymph nodes and Peyer's patches, as well as in other tissues, such as the skin and the gut. CCL21 plays a key role in the initiation and development of immune responses, as well as in the maintenance of immune homeostasis. In addition to its role in lymphocyte trafficking, CCL21 has also been implicated in other processes, such as wound healing and angiogenesis.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| C-C chemokine receptor type 7 | A C-C chemokine receptor type 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32248] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| tak 779 | |||
| cenicriviroc | cenicriviroc : A member of the class of benzazocines that is (5Z)-1,2,3,4-tetrahydro-1-benzazocine which is substituted by a 2-methylpropyl, N-{4-[(S)-(1-propyl-1H-imidazol-5-yl)methanesulfinyl]phenyl}carboxamide and 4-(2-butoxyethoxy)phenyl groups at positions 1, 5 and 8, respectively. It is a potent chemokine 2 and 5 receptor antagonist currently in development for the treatment of liver fibrosis in adults with nonalcoholic steatohepatitis (NASH). cenicriviroc: an inhibitor of HIV-1 | aromatic ether; benzazocine; diether; imidazoles; secondary carboxamide; sulfoxide | anti-HIV agent; anti-inflammatory agent; antirheumatic drug; chemokine receptor 2 antagonist; chemokine receptor 5 antagonist |