phosphatidylinositol phosphate 4-phosphatase activity

Definition

Target type: molecularfunction

Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate. [GOC:mah]

Phosphatidylinositol phosphate 4-phosphatases (PIP4Ps) are a family of enzymes that catalyze the dephosphorylation of phosphatidylinositol 4-phosphate (PIP2) to phosphatidylinositol (PI). This reaction is crucial for regulating cellular processes such as membrane trafficking, signal transduction, and cytoskeletal organization. PIP4Ps are involved in the turnover of PIP2, which is a key signaling molecule that participates in a wide range of cellular processes. PIP4Ps are localized to various cellular compartments, including the plasma membrane, Golgi apparatus, and endosomes, where they play specific roles in regulating membrane dynamics. For instance, PIP4Ps at the plasma membrane contribute to the regulation of endocytosis and exocytosis, while those located at the Golgi apparatus are involved in the sorting and trafficking of proteins. Moreover, PIP4Ps have been implicated in various cellular signaling pathways, such as the PI3K pathway and the Ras signaling pathway. By modulating the levels of PIP2, PIP4Ps influence the activation of signaling proteins and downstream effectors, thus impacting cellular functions. In summary, phosphatidylinositol phosphate 4-phosphatase activity is essential for maintaining cellular homeostasis by regulating the levels of PIP2, a key signaling molecule involved in diverse cellular processes.'
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Proteins (4)

Compounds (7)