Target type: molecularfunction
Enables the transfer of L-hydroxyproline from one side of a membrane to the other. [GOC:mah, PMID:14502423]
L-hydroxyproline transmembrane transporter activity refers to the movement of L-hydroxyproline across a cellular membrane. L-hydroxyproline is a modified amino acid found in collagen, a major component of connective tissues. This transporter activity is crucial for maintaining collagen synthesis and integrity.
The transporter protein facilitates the passive or active movement of L-hydroxyproline down or against its concentration gradient, respectively. This movement is driven by various mechanisms, including facilitated diffusion, secondary active transport, or primary active transport.
The transporter protein typically recognizes and binds L-hydroxyproline, undergoing a conformational change that allows the amino acid to pass through the membrane. This process is highly specific for L-hydroxyproline and may be regulated by factors such as substrate concentration, pH, and the presence of other molecules.
The molecular function of L-hydroxyproline transmembrane transporter activity plays a vital role in maintaining collagen homeostasis. Defects or mutations in this transporter can lead to various pathological conditions related to collagen metabolism, including connective tissue disorders, skeletal deformities, and impaired wound healing.'
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Protein | Definition | Taxonomy |
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Neutral amino acid transporter A | A neutral amino acid transporter A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43007] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
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hydroxyproline | hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group. Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation. | 4-hydroxyproline; L-alpha-amino acid zwitterion | human metabolite; mouse metabolite; plant metabolite |
serine | serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group. Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids. | L-alpha-amino acid; proteinogenic amino acid; serine; serine family amino acid; serine zwitterion | algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite |
glutamine | glutamine : An alpha-amino acid that consists of butyric acid bearing an amino substituent at position 2 and a carbamoyl substituent at position 4. Glutamine: A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells. L-glutamine : An optically active form of glutamine having L-configuration. | amino acid zwitterion; glutamine; glutamine family amino acid; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid | EC 1.14.13.39 (nitric oxide synthase) inhibitor; Escherichia coli metabolite; human metabolite; metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite |
asparagine | asparagine : An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 2-amino-2-oxoethyl group. Asparagine: A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed) | amino acid zwitterion; asparagine; aspartate family amino acid; L-alpha-amino acid; proteinogenic amino acid | Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite |
4-hydroxyphenylglycine, (s)-isomer | L-4-hydroxyphenylglycine : The L-enantiomer of 4-hydroxyphenylglycine. | 4-hydroxyphenylglycine | |
D-serine | D-alpha-amino acid; serine; serine zwitterion | Escherichia coli metabolite; human metabolite; NMDA receptor agonist | |
gamma-glutamine-4-nitroanilide | gamma-glutamine-4-nitroanilide: substrate for glutaminase B.; RN given refers to (L)-isomer | ||
proline | proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2. Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons. | amino acid zwitterion; glutamine family amino acid; L-alpha-amino acid; proline; proteinogenic amino acid | algal metabolite; compatible osmolytes; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite |