L-hydroxyproline transmembrane transporter activity

Definition

Target type: molecularfunction

Enables the transfer of L-hydroxyproline from one side of a membrane to the other. [GOC:mah, PMID:14502423]

L-hydroxyproline transmembrane transporter activity refers to the movement of L-hydroxyproline across a cellular membrane. L-hydroxyproline is a modified amino acid found in collagen, a major component of connective tissues. This transporter activity is crucial for maintaining collagen synthesis and integrity.

The transporter protein facilitates the passive or active movement of L-hydroxyproline down or against its concentration gradient, respectively. This movement is driven by various mechanisms, including facilitated diffusion, secondary active transport, or primary active transport.

The transporter protein typically recognizes and binds L-hydroxyproline, undergoing a conformational change that allows the amino acid to pass through the membrane. This process is highly specific for L-hydroxyproline and may be regulated by factors such as substrate concentration, pH, and the presence of other molecules.

The molecular function of L-hydroxyproline transmembrane transporter activity plays a vital role in maintaining collagen homeostasis. Defects or mutations in this transporter can lead to various pathological conditions related to collagen metabolism, including connective tissue disorders, skeletal deformities, and impaired wound healing.'
"

Proteins (1)

Compounds (8)