Target type: molecularfunction
Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans. [EC:3.2.1.84]
Glucan 1,3-alpha-glucosidase activity refers to the enzymatic ability to hydrolyze 1,3-alpha-glucosidic linkages in glucans. This enzyme specifically cleaves the glycosidic bond between the C1 atom of a glucose residue and the C3 atom of an adjacent glucose residue in a 1,3-beta-glucan chain. This activity is crucial for the degradation of 1,3-beta-glucans, which are polysaccharides found in the cell walls of certain fungi, bacteria, and algae. Glucan 1,3-alpha-glucosidases play a role in various biological processes, including: 1) **Fungal cell wall degradation:** They are involved in the breakdown of fungal cell walls, enabling the host organism to resist fungal infections. 2) **Immune response:** Some glucan 1,3-alpha-glucosidases are produced by immune cells, where they contribute to the recognition and degradation of fungal pathogens. 3) **Biofuel production:** These enzymes can be used in the production of biofuels from plant biomass, specifically by breaking down the complex polysaccharides in plant cell walls. 4) **Food industry:** Glucan 1,3-alpha-glucosidases are used in the food industry to modify the texture of food products, such as bread and cereals.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Neutral alpha-glucosidase AB | A neutral alpha-glucosidase AB that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14697] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| cisapride | cisapride : The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere. Cisapride: A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed) | benzamides | |
| 1-deoxynojirimycin | 1-deoxy-nojirimycin: structure in first source duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration. | 2-(hydroxymethyl)piperidine-3,4,5-triol; piperidine alkaloid | anti-HIV agent; anti-obesity agent; bacterial metabolite; EC 3.2.1.20 (alpha-glucosidase) inhibitor; hepatoprotective agent; hypoglycemic agent; plant metabolite |
| labetalol hydrochloride | salicylamides |