sweet taste receptor activity

Definition

Target type: molecularfunction

Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste. [GOC:mah]

Sweet taste receptor activity is a molecular function that involves the perception of sweet taste. This process is mediated by specialized taste receptor cells located on the tongue, palate, and epiglottis. These cells express taste receptor proteins, specifically the heterodimeric G protein-coupled receptors T1R2 and T1R3. When a sweet molecule binds to the T1R2/T1R3 receptor, it triggers a signaling cascade that ultimately leads to the generation of an action potential. This signal is transmitted to the brain via the gustatory nerve, where it is processed and interpreted as a sweet taste sensation. Sweet taste receptors are responsible for the perception of sweetness from a wide range of compounds, including sugars, artificial sweeteners, and amino acids. The ability to detect sweetness is crucial for survival, as it allows animals to identify and consume nutritious foods. It also plays a role in regulating food intake and maintaining energy balance. Sweet taste receptors are also implicated in the development of taste preferences and aversions. The specific molecular mechanisms involved in sweet taste receptor activity are complex and still under investigation. However, it is known that the process involves the activation of G protein-coupled receptors, the release of intracellular signaling molecules, and the generation of action potentials. Further research is needed to fully understand the molecular mechanisms of sweet taste receptor activity and their implications for human health and behavior.'
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Proteins (2)

Compounds (1)