Taste receptor type 1 member 3

A taste receptor type 1 member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTX0]

Sweet taste receptor T1R3

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
lactisole	Homo sapiens (human)	IC50	49.0225	12	0

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
lactisole	Homo sapiens (human)	EC50	7,417.5000	10	0

This protein enables 2 target(s):

Target	Category	Definition
taste receptor activity	molecular function	Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. [GOC:dph]
G protein-coupled receptor activity	molecular function	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]

This protein is located in 3 target(s):

Target	Category	Definition
Golgi apparatus	cellular component	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is part of 1 target(s):

Target	Category	Definition
sweet taste receptor complex	cellular component	A protein complex which is capable of sweet taste receptor activity. [GO_REF:0000088, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16720576]

This protein is involved in 4 target(s):

Target	Category	Definition
detection of chemical stimulus involved in sensory perception of sweet taste	biological process	The series of events required for a sweet taste stimulus to be received and converted to a molecular signal. [GOC:go_curators]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
sensory perception of sweet taste	biological process	The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]
sensory perception of umami taste	biological process	The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. This is a neurological process. [GOC:ai]