Taste receptor type 1 member 2

A taste receptor type 1 member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TE23]

G-protein coupled receptor 71;
Sweet taste receptor T1R2

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
lactisole	Homo sapiens (human)	IC50	60.2429	7	0

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
lactisole	Homo sapiens (human)	EC50	9,620.8333	6	0

This protein enables 2 target(s):

Target	Category	Definition
taste receptor activity	molecular function	Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. [GOC:dph]
G protein-coupled receptor activity	molecular function	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]

This protein is located in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is part of 2 target(s):

Target	Category	Definition
receptor complex	cellular component	Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]
sweet taste receptor complex	cellular component	A protein complex which is capable of sweet taste receptor activity. [GO_REF:0000088, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16720576]

This protein is involved in 4 target(s):

Target	Category	Definition
detection of chemical stimulus involved in sensory perception of sweet taste	biological process	The series of events required for a sweet taste stimulus to be received and converted to a molecular signal. [GOC:go_curators]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
positive regulation of cytokinesis	biological process	Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. [GOC:mah]
sensory perception of sweet taste	biological process	The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]