clathrin heavy chain binding

Definition

Target type: molecularfunction

Binding to a clathrin heavy chain. [GOC:mah]

Clathrin heavy chain binding is a critical molecular function involved in the formation and regulation of clathrin-coated vesicles, essential cellular structures responsible for the selective internalization of various molecules and macromolecules. Clathrin, a ubiquitous protein, assembles into triskelion-shaped structures that form the characteristic lattice of clathrin-coated vesicles. The interaction between clathrin heavy chain and its binding partners, including adaptor proteins (APs) and cargo receptors, is crucial for the recruitment and sorting of cargo molecules into these vesicles. This process begins with the recognition of specific cargo molecules by cargo receptors, which subsequently interact with adaptor proteins. The adaptor proteins, in turn, bind to the clathrin heavy chain, mediating the assembly of clathrin coats around the selected cargo. This assembly process is highly regulated, involving the dynamic interplay of multiple protein interactions and conformational changes. Once the clathrin-coated vesicle is formed, it buds off from the plasma membrane or other intracellular compartments, transporting the encapsulated cargo to its designated destination. The clathrin heavy chain binding function is therefore essential for a multitude of cellular processes, including receptor-mediated endocytosis, signal transduction, and nutrient uptake. Disruptions in clathrin heavy chain binding can lead to various cellular dysfunction and pathological conditions.'
"

Proteins (1)

Compounds (1)