Target type: molecularfunction
Binding to eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation. [GOC:mah]
Eukaryotic initiation factor 4G (eIF4G) binding is a crucial step in the initiation of protein synthesis in eukaryotes. eIF4G serves as a scaffold protein, bringing together different components of the translation initiation complex, including the mRNA, the small ribosomal subunit (40S), and the initiator methionine tRNA (Met-tRNAi).
The binding of eIF4G to the mRNA cap structure is mediated by the cap-binding protein eIF4E. This interaction is essential for recruiting the mRNA to the ribosome and initiating translation.
eIF4G also interacts with the poly(A) binding protein (PABP) bound to the poly(A) tail of the mRNA. This interaction promotes circularization of the mRNA, enhancing translation efficiency by facilitating ribosome recycling.
Furthermore, eIF4G interacts with eIF3, a large protein complex that binds to the 40S ribosomal subunit. This interaction helps to align the mRNA with the ribosome, facilitating the recruitment of the initiator tRNA.
In summary, eIF4G plays a pivotal role in bringing together the key components of the translation initiation complex, promoting mRNA circularization, and facilitating the alignment of the mRNA with the ribosome. These activities are essential for efficient and accurate protein synthesis in eukaryotic cells.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Eukaryotic translation initiation factor 4E | A eukaryotic translation initiation factor 4E that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06730] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| sirolimus | sirolimus : A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent. Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties. | antibiotic antifungal drug; cyclic acetal; cyclic ketone; ether; macrolide lactam; organic heterotricyclic compound; secondary alcohol | antibacterial drug; anticoronaviral agent; antineoplastic agent; bacterial metabolite; geroprotector; immunosuppressive agent; mTOR inhibitor |
| 6-mercapto-7-methylguanosine | 6-mercapto-7-methylguanosine: structure given in first source | ||
| cgp 57380 | CGP 57380: inhibits the mitogen-activated protein kinase-interacting kinase Mnk1 | pyrazolopyrimidine | |
| 7-methyl-GTP | guanosine 5'-phosphate |