6-mercapto-7-methylguanosine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 5494430 |
| CHEMBL ID | 1234483 |
| MeSH ID | M0201603 |
| Synonym |
|---|
| CHEMBL1234483 |
| 2-amino-9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-methylpurin-9-ium-6-thiolate |
| 6-mercapto-7-methylguanosine |
| 2-amino-6-mercapto-7-methylpurine ribonucleoside |
| 5f1954x1mn , |
| 1h-purinium, 2-amino-6,9-dihydro-7-methyl-9-beta-d-ribofuranosyl-6-thioxo-, hydroxide, inner salt |
| 2-amino-6,9-dihydro-7-methyl-9-beta-d-ribofuranosyl-6-thioxo-1h-purinium hydroxide, inner salt |
| unii-5f1954x1mn |
| 6-thio-7-methylguanosine |
| 1h-purinium, 2-amino-6,9-dihydro-7-methyl-9-.beta.-d-ribofuranosyl-6-thioxo-, inner salt |
| guanosine, 7-methyl-6-thio- |
| 2-amino-7-methyl-9-beta-d-ribofuranosyl-9h-purin-7-ium-6-thiolate |
| 7-methyl-6-thioguanosine (technical grade) |
| Q27261945 |
| PD018378 |
| DTXSID601235975 |
| AKOS040744092 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Eukaryotic translation initiation factor 4E | Homo sapiens (human) | IC50 (µMol) | 400.0000 | 3.0000 | 3.0000 | 3.0000 | AID241783 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| RNA cap binding | Eukaryotic translation initiation factor 4E | Homo sapiens (human) |
| RNA 7-methylguanosine cap binding | Eukaryotic translation initiation factor 4E | Homo sapiens (human) |
| RNA binding | Eukaryotic translation initiation factor 4E | Homo sapiens (human) |
| translation initiation factor activity | Eukaryotic translation initiation factor 4E | Homo sapiens (human) |
| protein binding | Eukaryotic translation initiation factor 4E | Homo sapiens (human) |
| enzyme binding | Eukaryotic translation initiation factor 4E | Homo sapiens (human) |
| eukaryotic initiation factor 4G binding | Eukaryotic translation initiation factor 4E | Homo sapiens (human) |
| mRNA cap binding | Eukaryotic translation initiation factor 4E | Homo sapiens (human) |
| DNA-binding transcription factor binding | Eukaryotic translation initiation factor 4E | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID241783 | Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E | 2005 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 15, Issue:8 | Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 11 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||