| Assay ID | Title | Year | Journal | Article |
|---|
| AID476963 | Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4
| Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP. |
| AID1241167 | Stability of the compound in 10% fetal bovine serum at 50 uM up to 240 mins by RP-HPLC analysis | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Phosphate-modified analogues of m(7)GTP and m(7)Gppppm(7)G-Synthesis and biochemical properties. |
| AID423563 | Stability in presence of human DcpS assessed as complete degradation at 40 uM by HPLC-based assay | 2009 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7
| Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation. |
| AID423564 | Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-capped 5'UTRbetaglob-LUC mRNA translation by luciferase-based luminometry | 2009 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7
| Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation. |
| AID476965 | Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in absence of KKRYDREFLLGFQFIFA | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4
| Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP. |
| AID674494 | Inhibition of Ascaris suum eIF4E-3 assessed as inhibition of cap-dependent translation after 1 hr by cell-free Renilla luciferase reporter gene assay | 2012 | Bioorganic & medicinal chemistry, Aug-01, Volume: 20, Issue:15
| Synthesis of N²-modified 7-methylguanosine 5'-monophosphates as nematode translation inhibitors. |
| AID476964 | Binding affinity to mouse eIF4E expressed in Escherichia coli assessed as fluorescence quenching by time-synchronized fluorescence titration assay in presence of KKRYDREFLLGFQFIFA | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4
| Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP. |
| AID1241168 | Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence based luciferase assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Phosphate-modified analogues of m(7)GTP and m(7)Gppppm(7)G-Synthesis and biochemical properties. |
| AID423562 | Binding affinity to mouse eukaryotic initiation factor 4E expressed in Escherichia coli BL21(DE3) by fluorescence quenching titration method | 2009 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7
| Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation. |
| AID669612 | Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction. |
| AID1241164 | Stability of the compound assessed as human DcpS-mediated compound hydrolysis at 40 uM after 10 to 180 mins by HPLC analysis | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Phosphate-modified analogues of m(7)GTP and m(7)Gppppm(7)G-Synthesis and biochemical properties. |
| AID423565 | Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-capped 5'UTRbetaglob-LUC mRNA translation treated 60 mins before mRNA addition by luciferase-based luminome | 2009 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7
| Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation. |
| AID423566 | Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of rabbit beta-globulin mRNA translation by [3H]leucine incorporation assay | 2009 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7
| Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation. |
| AID1241169 | Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by luminescence based luciferase assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Phosphate-modified analogues of m(7)GTP and m(7)Gppppm(7)G-Synthesis and biochemical properties. |
| AID476966 | Binding affinity to mouse eIF4E expressed in Escherichia coli assessed as fluorescence quenching by time-synchronized fluorescence titration assay in absence of KKRYDREFLLGFQFIFA | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4
| Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP. |
| AID1241163 | Binding affinity to eIF4E (unknown origin) by fluorescence quenching assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Phosphate-modified analogues of m(7)GTP and m(7)Gppppm(7)G-Synthesis and biochemical properties. |
| AID1241166 | Stability of the compound in 5% fetal bovine serum at 50 uM up to 240 mins by RP-HPLC analysis | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Phosphate-modified analogues of m(7)GTP and m(7)Gppppm(7)G-Synthesis and biochemical properties. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |