Gene Targets > calcium-dependent ATPase activity
Page last updated: 2024-10-24

calcium-dependent ATPase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+). [GOC:mah]

Calcium-dependent ATPase activity is a fundamental enzymatic process that utilizes the hydrolysis of adenosine triphosphate (ATP) to transport calcium ions (Ca2+) across cellular membranes. This activity is crucial for maintaining calcium homeostasis, a critical factor in various cellular functions, including muscle contraction, neurotransmission, cell signaling, and apoptosis.

The mechanism involves the enzyme, a calcium-dependent ATPase, binding to calcium ions on one side of the membrane. This binding triggers conformational changes within the enzyme, leading to the hydrolysis of ATP. The energy released from ATP hydrolysis is then used to pump calcium ions across the membrane against their concentration gradient.

There are several types of calcium-dependent ATPases, each with a specific function and localization within the cell. For instance, the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pumps calcium ions from the cytoplasm into the sarcoplasmic reticulum of muscle cells, contributing to muscle relaxation. The plasma membrane Ca2+-ATPase (PMCA) expels calcium ions from the cytoplasm into the extracellular space, maintaining low intracellular calcium levels.

In addition to their role in calcium homeostasis, calcium-dependent ATPases are also involved in other cellular processes. For example, they participate in the regulation of cell growth and differentiation, as well as the maintenance of cell structure and integrity.

Dysregulation of calcium-dependent ATPase activity can lead to various pathological conditions, including muscle weakness, cardiac arrhythmias, and neurodegenerative diseases. Therefore, understanding the molecular function of this activity is essential for developing therapies to treat these disorders.'
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Proteins (2)

ProteinDefinitionTaxonomy
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3A sarcoplasmic/endoplasmic reticulum calcium ATPase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q93084]Homo sapiens (human)
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 A sarcoplasmic/endoplasmic reticulum calcium ATPase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14983]Homo sapiens (human)

Compounds (7)

CompoundDefinitionClassesRoles
2,5-di-tert-butylhydroquinone2,5-di-tert-butylbenzene-1,4-diol : A member of the class of hydroquinones that is benzene-1,4-diol substituted by tert-butyl groups at position 2 and 5.hydroquinones
chelerythrinechelerythrine : A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.benzophenanthridine alkaloid;
organic cation		antibacterial agent;
antineoplastic agent;
EC 2.7.11.13 (protein kinase C) inhibitor
paxillinepaxilline : An indole diterpene alkaloid with formula C27H33NO4 isolated from Penicillium paxilli. It is a potent inhibitor of large conductance Ca2(+)- and voltage-activated K(+) (BK)-type channels.

paxilline: structure given in first source; RN given refers to (2R-(2alpha,4bbeta,6aalpha,12bbeta,12calpha,14abeta))-isomer		diterpene alkaloid;
enone;
organic heterohexacyclic compound;
terpenoid indole alkaloid;
tertiary alcohol		anticonvulsant;
Aspergillus metabolite;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor;
genotoxin;
geroprotector;
mycotoxin;
Penicillium metabolite;
potassium channel blocker
thapsigarginthapsigargin : An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.

Thapsigargin: A sesquiterpene lactone found in roots of THAPSIA. It inhibits SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES.		butyrate ester;
organic heterotricyclic compound;
sesquiterpene lactone		calcium channel blocker;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor
curcumincurcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.

Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.		aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
biselyngbyasidebiselyngbyaside: antineoplastic from the marine cyanobacterium Lyngbya sp.; structure in first source
alpha-cyclopiazonic acidalpha-cyclopiazonic acids