MAP kinase tyrosine/serine/threonine phosphatase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate. [GOC:mah, PMID:12184814]
MAP kinase tyrosine/serine/threonine phosphatase activity is a critical regulatory mechanism in cellular signaling pathways. It specifically removes phosphate groups from tyrosine, serine, and threonine residues within MAP kinases, which are key components of signaling cascades that regulate a diverse range of cellular processes. These processes include cell proliferation, differentiation, survival, and stress responses. The removal of phosphate groups by MAP kinase phosphatases deactivates MAP kinases, effectively terminating their signaling activity. This dephosphorylation event is essential for maintaining a balance in cellular signaling and preventing uncontrolled activation of MAP kinase pathways, which can lead to pathological conditions such as cancer. The specificity of MAP kinase phosphatases for MAP kinases ensures that they are not involved in the regulation of other signaling pathways. This specificity is achieved through the presence of specific binding sites and active sites within the phosphatase that recognize and interact with the MAP kinase substrates. These phosphatases often work in concert with other signaling molecules to fine-tune MAP kinase activity in response to specific stimuli. Understanding the molecular function of MAP kinase tyrosine/serine/threonine phosphatase activity is crucial for comprehending the complexity of cellular signaling and for developing therapeutic strategies targeting these enzymes in disease.'
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Proteins (2)
| Protein | Definition | Taxonomy |
|---|---|---|
| Dual specificity protein phosphatase 5 | A dual specificity protein phosphatase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16690] | Homo sapiens (human) |
| Dual specificity protein phosphatase 2 | A dual specificity protein phosphatase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05923] | Homo sapiens (human) |
Compounds (3)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| suramin | suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years. Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. | naphthalenesulfonic acid; phenylureas; secondary carboxamide | angiogenesis inhibitor; antinematodal drug; antineoplastic agent; apoptosis inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; GABA antagonist; GABA-gated chloride channel antagonist; purinergic receptor P2 antagonist; ryanodine receptor agonist; trypanocidal drug |
| nsc-87877 | NSC-87877: potent Shp2 (nonreceptor protein tyrosine phosphatase) inhibitor; structure in first source | ||
| mk-0893 |