Dual specificity protein phosphatase 2

A dual specificity protein phosphatase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05923]

EC 3.1.3.16;
EC 3.1.3.48;
Dual specificity protein phosphatase PAC-1

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
mk-0893	Homo sapiens (human)	IC50	9.2000	1	1

This protein enables 7 target(s):

Target	Category	Definition
protein tyrosine phosphatase activity	molecular function	Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
myosin phosphatase activity	molecular function	Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. [EC:3.1.3.16]
mitogen-activated protein kinase binding	molecular function	Binding to a mitogen-activated protein kinase. [GOC:ai]
MAP kinase tyrosine/serine/threonine phosphatase activity	molecular function	Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate. [GOC:mah, PMID:12184814]
MAP kinase tyrosine phosphatase activity	molecular function	Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate. [GOC:mah]
protein tyrosine/threonine phosphatase activity	molecular function	Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [GOC:mah]

This protein is located in 2 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
nuclear membrane	cellular component	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz]

This protein is active in 2 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

This protein is involved in 4 target(s):

Target	Category	Definition
protein dephosphorylation	biological process	The process of removing one or more phosphoric residues from a protein. [GOC:hb]
endoderm formation	biological process	The formation of the endoderm during gastrulation. [GOC:go_curators]
negative regulation of MAPK cascade	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. [GOC:go_curators]
peptidyl-tyrosine dephosphorylation	biological process	The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. [GOC:bf]