Page last updated: 2024-10-24

dipeptidase activity

Definition

Target type: molecularfunction

Catalysis of the hydrolysis of a dipeptide. [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]

Dipeptidase activity refers to the enzymatic hydrolysis of dipeptides, which are molecules composed of two amino acids linked by a peptide bond. These enzymes play a crucial role in protein digestion and metabolism, breaking down dipeptides into their constituent amino acids. This process is essential for the absorption and utilization of amino acids by the body. Dipeptidases are highly specific for the type of amino acids present in the dipeptide substrate, and their activity can be influenced by factors such as pH, temperature, and the presence of inhibitors. Dipeptidases are found in various organisms, including bacteria, fungi, plants, and animals, and they are involved in a range of physiological processes. For example, in humans, dipeptidases are present in the small intestine, where they contribute to the final stages of protein digestion. They are also found in other tissues, such as the kidneys and liver, where they play roles in amino acid metabolism and detoxification.'
"

Proteins (3)

ProteinDefinitionTaxonomy
Cytosol aminopeptidase[no definition available]Bos taurus (cattle)
N-acetylated-alpha-linked acidic dipeptidase 2An N-acetylated-alpha-linked acidic dipeptidase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y3Q0]Homo sapiens (human)
Glutamate carboxypeptidase 2A glutamate carboxypeptidase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q04609]Homo sapiens (human)

Compounds (16)

CompoundDefinitionClassesRoles
glutamic acidglutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.

Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid
Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
2-aminotetralin2-aminotetralin: RN given refers to parent cpd without isomeric designation; structuretetralins
quisqualic acidQuisqualic Acid: An agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis.non-proteinogenic alpha-amino acid
beta-tetralone
plasmenylserineO-phospho-L-serine : The L-enantiomer of O-phosphoserine.

O-phosphoserine : A serine derivative that is serine substituted at the oxygen atom by a phosphono group.

plasmenylserine: RN given refers to (L)-isomer
O-phosphoserineEC 1.4.7.1 [glutamate synthase (ferredoxin)] inhibitor;
EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitor;
EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ubenimexubenimex: growth inhibitor
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
serine o-sulfateL-serine O-sulfate : A non-proteinogenic L-alpha-amino acid that is the O-sulfo derivative of L-serine.

serine O-sulfate: RN given refers to (L)-isomer
L-serine derivative;
non-proteinogenic L-alpha-amino acid;
O-sulfoamino acid
isospaglumic acidAc-Asp-Glu : A dipeptide composed of N-acetyl-L-aspartic acid and L-glutamic acid joined by a peptide linkage.

isospaglumic acid: mediator in the sensitivity of animals to hyperbaric oxygenation; Naaxia is the tradename; apparently can have both a neuroprotective and a neurotoxic effect
dipeptidehuman metabolite
sq 14,6032-benzyl-3-mercaptopropanoic acid: structure; carboxypeptidase inhibitor
willardiine3-(uracil-1-yl)-L-alanine : The 3-(uracil-1-yl) derivative of L-alanine.

willardiine: isolated from seeds of Acacia willariana; structure
amino acid zwitterion;
L-alanine derivative;
non-proteinogenic L-alpha-amino acid
gamma-glutamyl hydroxamateglutamine hydroxamate : A hydroxamic acid that is L-glutamine hydroxylated at N-5.amino acid zwitterion;
glutamic acid derivative;
hydroxamic acid
phenobarbital sodium2-(phosphonomethyl)pentanedioic acid: an N-acetylated alpha-linked acidic dipeptidase (NAALADase) antagonist
gpi 56932-(3-mercaptopropyl)pentanedioic acid: inhibits glutamate carboxypeptidase II; structure in first source
zj43ZJ43: N-acetylaspartylglutamate (NAAG) peptidase inhibitor; structure in first source
psma-617PSMA-617: inhibits prostate-specific membrane antigen; structure in first source