Page last updated: 2024-10-24

cholesterol monooxygenase (side-chain-cleaving) activity

Definition

Target type: molecularfunction

Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O. [EC:1.14.15.6]

Proteins (3)

ProteinDefinitionTaxonomy
Cholesterol side-chain cleavage enzyme, mitochondrial A cytochrome P450 11A1, mitochondrial that is encoded in the genome of cow. [OMA:P00189, PRO:DNx]Bos taurus (cattle)
Cholesterol side-chain cleavage enzyme, mitochondrialA cytochrome P450 11A1, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05108]Homo sapiens (human)
Cholesterol side-chain cleavage enzyme, mitochondrialA cytochrome P450 11A1, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05108]Homo sapiens (human)

Compounds (3)

CompoundDefinitionClassesRoles
aminoglutethimideaminoglutethimide : A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.

Aminoglutethimide: An aromatase inhibitor that is used in the treatment of advanced BREAST CANCER.
dicarboximide;
piperidones;
substituted aniline
adrenergic agent;
anticonvulsant;
antineoplastic agent;
EC 1.14.14.14 (aromatase) inhibitor
voriconazolevoriconazole : A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4.

Voriconazole: A triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.
conazole antifungal drug;
difluorobenzene;
pyrimidines;
tertiary alcohol;
triazole antifungal drug
P450 inhibitor
cyclohexylaminoglutethimidecyclohexylaminoglutethimide: structure given in first source