Page last updated: 2024-10-24

structural constituent of muscle

Definition

Target type: molecularfunction

The action of a molecule that contributes to the structural integrity of a muscle fiber. [GOC:mah]

Structural constituent of muscle is a molecular function that describes proteins involved in the formation and maintenance of muscle tissue. These proteins provide the structural framework and support for muscle fibers, enabling them to contract and generate force. They play a crucial role in muscle development, growth, and repair.

Muscle proteins involved in this function can be categorized as follows:

1. **Contractile Proteins:** These proteins are responsible for the actual shortening of muscle fibers during contraction. Key examples include actin and myosin, which form the sliding filament system that generates muscle force.

2. **Scaffolding Proteins:** These proteins provide structural support and organization to the muscle fiber. Examples include titin, which acts as a giant spring connecting the Z-disk to the M-line of the sarcomere, and nebulin, which acts as a ruler for the length of actin filaments.

3. **Regulatory Proteins:** These proteins control the initiation and termination of muscle contraction. They include troponin and tropomyosin, which regulate the interaction between actin and myosin.

4. **Other Structural Proteins:** This category includes proteins that contribute to the stability and integrity of the muscle fiber. Examples include dystrophin, which connects the cytoskeleton of muscle cells to the extracellular matrix, and laminin, which is involved in the attachment of muscle fibers to the basement membrane.

These structural proteins work together to form a complex and highly organized system that enables muscles to perform their essential functions in locomotion, breathing, and other bodily movements.'
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Proteins (1)

ProteinDefinitionTaxonomy
Aspartyl/asparaginyl beta-hydroxylaseAn aspartyl/asparaginyl beta-hydroxylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12797]Homo sapiens (human)

Compounds (10)

CompoundDefinitionClassesRoles
gossypolGossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
2,4-pyridinedicarboxylic acidlutidinic acid : A pyridinedicarboxylic acid carrying carboxy groups at positions 2 and 4.pyridinedicarboxylic acid
bleomycinbleomycinantineoplastic agent;
metabolite
tubacintubacin: inhibits histone deacetylase 6; structure in first source1,3-oxazoles
belinostathydroxamic acid;
olefinic compound;
sulfonamide
antineoplastic agent;
EC 3.5.1.98 (histone deacetylase) inhibitor
midostaurinmidostaurin : An organic heterooctacyclic compound that is the N-benzoyl derivative of staurosporine.benzamides;
gamma-lactam;
indolocarbazole;
organic heterooctacyclic compound
antineoplastic agent;
EC 2.7.11.13 (protein kinase C) inhibitor
abt-737aromatic amine;
aryl sulfide;
biphenyls;
C-nitro compound;
monochlorobenzenes;
N-arylpiperazine;
N-sulfonylcarboxamide;
secondary amino compound;
tertiary amino compound
anti-allergic agent;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor
navitoclaxaryl sulfide;
monochlorobenzenes;
morpholines;
N-sulfonylcarboxamide;
organofluorine compound;
piperazines;
secondary amino compound;
sulfone;
tertiary amino compound
antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor
plx4032aromatic ketone;
difluorobenzene;
monochlorobenzenes;
pyrrolopyridine;
sulfonamide
antineoplastic agent;
B-Raf inhibitor
abt-199venetoclax : A member of the class of pyrrolopyridines that is a potent inhibitor of the antiapoptotic protein B-cell lymphoma 2. It is used for treamtment of chronic lymphocytic leukemia with 17p deletion.

venetoclax: A BCL-2 inhibitor with antineoplastic activity that is used in the treatment of CHRONIC LYMPHOCYTIC LEUKEMIA associated with chromosome 17p deletion; structure in first source.
aromatic ether;
C-nitro compound;
monochlorobenzenes;
N-alkylpiperazine;
N-arylpiperazine;
N-sulfonylcarboxamide;
oxanes;
pyrrolopyridine
antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor