acetylcholine:proton antiporter activity

Definition

Target type: molecularfunction

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out). [TC:2.A.1.2.13]

Acetylcholine:proton antiporter activity is a molecular function that describes the transmembrane transport of both acetylcholine and protons across biological membranes. This process is driven by the electrochemical gradient of protons, meaning that the movement of protons across the membrane provides the energy for the simultaneous transport of acetylcholine. Acetylcholine:proton antiporters are integral membrane proteins that typically have multiple transmembrane domains. They play a crucial role in regulating the concentration of both acetylcholine and protons within specific cellular compartments. The transport of acetylcholine by these antiporters can influence the activity of cholinergic synapses, while the transport of protons contributes to the maintenance of pH homeostasis. For example, acetylcholine:proton antiporters are found in the presynaptic terminal of cholinergic neurons, where they facilitate the removal of acetylcholine from the synaptic cleft after neurotransmission. This process ensures the efficient and rapid termination of synaptic signaling. Additionally, acetylcholine:proton antiporters are also implicated in the regulation of intracellular pH in various tissues. Their activity can affect the activity of pH-sensitive enzymes and other cellular processes. Overall, acetylcholine:proton antiporter activity represents a vital mechanism for regulating the transport of both acetylcholine and protons across biological membranes, thereby impacting a range of physiological functions.'
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Proteins (1)

Compounds (5)