stem cell factor receptor binding

Definition

Target type: molecularfunction

Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor. [GOC:jl, PMID:10698217]

Stem cell factor receptor (c-Kit) binding is a crucial step in the regulation of various cellular processes, particularly in hematopoiesis, melanogenesis, and gametogenesis. The interaction between stem cell factor (SCF) and c-Kit initiates a signaling cascade that ultimately leads to cellular proliferation, differentiation, survival, and migration.

Upon binding of SCF to its receptor c-Kit, a transmembrane receptor tyrosine kinase, a conformational change occurs in the receptor, resulting in the activation of its intrinsic tyrosine kinase activity. This activation leads to autophosphorylation of c-Kit on specific tyrosine residues within its cytoplasmic domain. These phosphorylated tyrosine residues serve as docking sites for various intracellular signaling molecules, such as adaptor proteins, phospholipase Cγ (PLCγ), and phosphatidylinositol 3-kinase (PI3K).

The recruitment of these signaling molecules initiates downstream signaling pathways, including the Ras-MAPK pathway, the PI3K-Akt pathway, and the PLCγ pathway. The Ras-MAPK pathway promotes cell proliferation and survival by activating transcription factors that regulate gene expression involved in these processes. The PI3K-Akt pathway also contributes to cell survival and growth by inhibiting apoptosis. The PLCγ pathway triggers intracellular calcium release, which plays a role in cell migration and differentiation.

In summary, the binding of SCF to c-Kit initiates a complex signaling cascade that regulates a wide range of cellular processes, including cell proliferation, differentiation, survival, and migration. These processes are essential for normal development, tissue homeostasis, and immune function. The disruption of this signaling pathway can lead to various diseases, such as leukemia, mastocytosis, and infertility.'
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Proteins (1)

Compounds (2)