Target type: molecularfunction
Binding to a vascular endothelial growth factor receptor. [GOC:ai]
Vascular endothelial growth factor receptor (VEGFR) binding is a crucial step in the process of angiogenesis, the formation of new blood vessels. This molecular function involves the interaction between VEGF, a potent angiogenic growth factor, and its cognate receptors, VEGFRs, which are transmembrane tyrosine kinases. VEGF binding to VEGFR triggers a cascade of intracellular signaling events that ultimately lead to the proliferation, migration, and differentiation of endothelial cells, the cells that line blood vessels. The binding event occurs within the extracellular domain of VEGFR, which comprises seven immunoglobulin-like domains. These domains recognize and bind to the specific amino acid sequence of VEGF, initiating the signaling cascade. The initial binding of VEGF to VEGFR causes a conformational change in the receptor, leading to its dimerization. This dimerization brings together the intracellular tyrosine kinase domains of the receptor, activating their enzymatic activity. The activated tyrosine kinases then phosphorylate downstream signaling molecules, including phospholipase C-gamma (PLC-gamma), phosphatidylinositol 3-kinase (PI3K), and mitogen-activated protein kinase (MAPK) pathways. These pathways stimulate various cellular processes, including endothelial cell survival, proliferation, migration, and the formation of new blood vessels. The VEGF-VEGFR interaction is essential for normal development, wound healing, and tissue repair. However, dysregulation of this process can contribute to various diseases, including cancer, diabetic retinopathy, and rheumatoid arthritis. Therefore, targeting VEGF-VEGFR binding has become a major therapeutic strategy for treating these conditions.'
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Protein | Definition | Taxonomy |
---|---|---|
Placenta growth factor | A placenta growth factor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49763] | Homo sapiens (human) |
Vascular endothelial growth factor A | A vascular endothelial growth factor A, long form that is encoded in the genome of human. [PRO:DNx, UniProtKB:P15692] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
4-phenylphenol | 4-phenylphenol: RN given refers to cpd without isomeric designation biphenyl-4-ol : A member of the class of hydroxybiphenyls that is biphenyl carrying a hydroxy group at position 4. | hydroxybiphenyls | |
4-phenylbenzoic acid | 4-phenylbenzoic acid: RN given refers to 4-carboxylic cpd | ||
amentoflavone | biflavonoid; hydroxyflavone; ring assembly | angiogenesis inhibitor; antiviral agent; cathepsin B inhibitor; P450 inhibitor; plant metabolite | |
proanthocyanidin a1 | procyanidin A1: from aqueous extract of peanut skin; structure in first source | flavonoid oligomer | |
phosphomannopentaose sulfate | phosphomannopentaose sulfate: structure in first source |