galanin receptor activity

Definition

Target type: molecularfunction

Combining with galanin to initiate a change in cell activity. [GOC:ai]

Galanin receptors are G protein-coupled receptors (GPCRs) that mediate the actions of the neuropeptide galanin. Galanin is involved in a wide range of physiological processes, including feeding, stress response, and pain perception. The binding of galanin to its receptor activates a signaling cascade that involves the activation of G proteins, which in turn can activate various downstream effectors, including adenylyl cyclase, phospholipase C, and ion channels. The activation of these downstream effectors leads to a variety of cellular responses, including changes in gene expression, intracellular calcium levels, and membrane potential. Galanin receptors are found in the central nervous system, peripheral nervous system, and a variety of other tissues. The specific molecular function of galanin receptor activity varies depending on the tissue and cell type in which the receptor is expressed. For example, in the brain, galanin receptors are involved in the regulation of mood, anxiety, and cognition. In the gut, galanin receptors regulate gastrointestinal motility and secretion. And in the cardiovascular system, galanin receptors play a role in the regulation of heart rate and blood pressure.'
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Proteins (3)

Compounds (14)