Page last updated: 2024-10-24

inositol-polyphosphate 5-phosphatase activity

Definition

Target type: molecularfunction

Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. [EC:3.1.3.56]

Inositol-polyphosphate 5-phosphatases are a group of enzymes that catalyze the hydrolysis of the 5-phosphate group from inositol polyphosphates. These enzymes play crucial roles in a wide range of cellular processes, including signal transduction, membrane trafficking, and cytoskeletal organization. Inositol polyphosphates are signaling molecules that are involved in various cellular processes, including calcium signaling, phosphoinositide signaling, and actin cytoskeleton organization. Inositol-polyphosphate 5-phosphatases regulate the levels of these signaling molecules by removing the 5-phosphate group, thus modulating their activity. The reaction catalyzed by inositol-polyphosphate 5-phosphatases involves the removal of the 5-phosphate group from inositol polyphosphates, generating a corresponding inositol polyphosphate with one less phosphate group. This reaction is highly specific and typically requires the presence of divalent metal ions such as magnesium or manganese. The molecular function of inositol-polyphosphate 5-phosphatases is thus to dephosphorylate inositol polyphosphates at the 5-position, thereby regulating their signaling activity and influencing a wide range of cellular processes.'
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Proteins (2)

ProteinDefinitionTaxonomy
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15357]Homo sapiens (human)
Inositol polyphosphate-5-phosphatase AAn inositol polyphosphate-5-phosphatase A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14642]Homo sapiens (human)

Compounds (7)

CompoundDefinitionClassesRoles
2-(4-hydroxyphenyl)-5,6,7,8-tetrahydroxy-4H-1-benzopyran-4-one2-(4-hydroxyphenyl)-5,6,7,8-tetrahydroxy-4H-1-benzopyran-4-one : A pentahydroxyflavone that is flavone substituted by hydroxy groups at positions 5, 6, 7, 8, and 4' respectively.pentahydroxyflavone
inositol-1,3,4,5-tetrakisphosphate1D-myo-inositol 1,3,4,5-tetrakisphosphate : A myo-inositol tetrakisphosphate having the four phosphates placed in the 1-, 3-, 4- and 5-positions.

inositol-1,3,4,5-tetrakisphosphate: for cpd without numerical locants of phosphate groups, index INOSITOL PHOSPHATES
inositol phosphate
nsc-89199estramustine phosphate : A steroid phosphate which is the 17-O-phospho derivative of estramustine.carbamate ester;
organochlorine compound;
steroid phosphate
inositol 1,4,5-trisphosphateInositol 1,4,5-Trisphosphate: Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.myo-inositol trisphosphatemouse metabolite
crizotinibcrizotinib : A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that has R configuration at the chiral centre. The active enantiomer, it acts as a kinase inhibitor and is used for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)

Crizotinib: A piperidine and aminopyridine derivative that acts as an inhibitor of RECEPTOR PROTEIN-TYROSINE KINASES, including ANAPLASTIC LYMPHOMA KINASE (ALK) and HEPATOCYTE GROWTH FACTOR RECEPTOR (HGFR; c-Met). It is used in the treatment of NON-SMALL CELL LUNG CANCER.
3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amineantineoplastic agent;
biomarker;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
as1949490
galloflavingalloflavin: structure in first source