Page last updated: 2024-10-24

3-chloroallyl aldehyde dehydrogenase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid. [UM-BBD_enzymeID:e0432]

3-Chloroallyl aldehyde dehydrogenase activity is an enzymatic activity involved in the detoxification of xenobiotics, specifically the oxidation of 3-chloroallyl aldehyde. The enzyme catalyzes the conversion of 3-chloroallyl aldehyde, a toxic and reactive molecule, into the less toxic 3-chloroacrylic acid. This reaction involves the transfer of hydride ions from the aldehyde to the nicotinamide adenine dinucleotide (NAD+) cofactor, resulting in the reduction of NAD+ to NADH and the oxidation of the aldehyde to a carboxyl group. This process is essential for the detoxification of 3-chloroallyl aldehyde and the prevention of its harmful effects on cells and tissues.'
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Proteins (2)

ProteinDefinitionTaxonomy
Aldehyde dehydrogenase, dimeric NADP-preferring An aldehyde dehydrogenase, dimeric NADP-preferring that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30838]Homo sapiens (human)
Retinal dehydrogenase 2A retinal dehydrogenase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94788]Homo sapiens (human)

Compounds (7)

CompoundDefinitionClassesRoles
4-nitrobenzaldehyde4-nitrobenzaldehyde : A C-nitro compound that is benzaldehyde substituted at the para-position with a nitro group.

4-nitrobenzaldehyde: RN given refers to parent cpd
benzaldehydes;
C-nitro compound
uvitex swnUvitex SWN: optical brightner from Ciba; structure7-aminocoumarinsfluorochrome
win 18446WIN 18446 : A carboxamide that is 1,8-diaminooctane in which a hydrogen attached to each of the amino groups has been replaced by a dichloroacetyl group. Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis. It down-regulates sex related genes in zebrafish.organochlorine compound;
secondary carboxamide
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor
4-(diethylamino)benzaldehyde4-(diethylamino)benzaldehyde : A member of the class of benzaldehydes carrying a diethylamino substituent at position 4.aromatic amine;
benzaldehydes;
tertiary amino compound
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor
daidzindaidzein 7-O-beta-D-glucoside : A glycosyloxyisoflavone that is daidzein attached to a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage. It is used in the treatment of alcohol dependency (antidipsotropic).

daidzin: a potent, selective, and reversible inhibitor of human mitochondrial aldehyde dehydrogenase
7-hydroxyisoflavones 7-O-beta-D-glucoside;
hydroxyisoflavone;
monosaccharide derivative
plant metabolite
7-butyl-8-[[4-(3-chlorophenyl)-1-piperazinyl]methyl]-1,3-dimethylpurine-2,6-dionepiperazines
1-(4-chlorophenyl)sulfonyl-2-benzimidazolaminesulfonamide