PCSK9-LDLR complex

Definition

Target type: cellularcomponent

A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway. [GOC:BHF, GOC:nc, PMID:18250299, PMID:24440079]

The PCSK9-LDLR complex is a protein complex that forms in the extracellular space of cells. It is composed of two proteins: proprotein convertase subtilisin/kexin type 9 (PCSK9) and low-density lipoprotein receptor (LDLR). PCSK9 is a serine protease that binds to LDLR and prevents it from recycling back to the cell surface after internalizing cholesterol-containing LDL. This results in an accumulation of LDL in the bloodstream, increasing the risk of heart disease. The complex forms through a series of interactions between the two proteins. PCSK9 binds to the epidermal growth factor-like repeat A (EGFA) domain of LDLR, which is located in the extracellular portion of the receptor. This interaction is mediated by a series of electrostatic interactions between the two proteins. Once PCSK9 has bound to LDLR, it undergoes a conformational change that allows it to cleave the LDLR molecule. This cleavage event disrupts the ability of LDLR to bind LDL and to recycle back to the cell surface. The PCSK9-LDLR complex is therefore located at the cell surface, where it interacts with LDL particles.'
```
"

Proteins (2)

Compounds (2)