Page last updated: 2024-10-24

clathrin-sculpted monoamine transport vesicle membrane

Definition

Target type: cellularcomponent

The lipid bilayer surrounding a clathrin-sculpted monoamine transport vesicle. [GOC:mg2]

The clathrin-sculpted monoamine transport vesicle membrane is a specialized cellular component involved in the regulated transport of monoamine neurotransmitters. It is a dynamic structure that undergoes a complex series of events during its formation, cargo loading, and fusion with the plasma membrane. The membrane is characterized by its association with clathrin, a protein that forms a lattice-like cage around the vesicle. This clathrin coat provides structural support and helps to drive vesicle budding from the donor compartment. The membrane also contains a variety of other proteins, including adaptor proteins, sorting signals, and transmembrane receptors, which are involved in the selective packaging of monoamine neurotransmitters into the vesicle lumen. Monoamine transporters, such as dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT), are embedded in the vesicle membrane. They play a crucial role in the uptake of monoamines from the cytoplasm into the vesicle lumen. The membrane also contains V-type ATPases, which are proton pumps that maintain the electrochemical gradient necessary for efficient monoamine transport. Once the vesicle is fully loaded with neurotransmitters, it detaches from the donor compartment and moves towards the plasma membrane for exocytosis. At the plasma membrane, the vesicle fuses with the cell surface, releasing its cargo of neurotransmitters into the synaptic cleft, where they can bind to postsynaptic receptors and initiate signaling.'
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Proteins (4)

ProteinDefinitionTaxonomy
Synaptic vesicular amine transporterA synaptic vesicular amine transporter that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05940]Homo sapiens (human)
Chromaffin granule amine transporterA chromaffin granule amine transporter that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54219]Homo sapiens (human)
Synaptic vesicular amine transporterA synaptic vesicular amine transporter that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05940]Homo sapiens (human)
Chromaffin granule amine transporterA chromaffin granule amine transporter that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54219]Homo sapiens (human)

Compounds (9)

CompoundDefinitionClassesRoles
ketanserinketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.

Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
aromatic ketone;
organofluorine compound;
piperidines;
quinazolines
alpha-adrenergic antagonist;
antihypertensive agent;
cardiovascular drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
serotonergic antagonist
reserpinereserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.

Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
alkaloid ester;
methyl ester;
yohimban alkaloid
adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic
tetrabenazine9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one : A benzoquinolizine that is 1,2,3,4,4a,9,10,10a-octahydrophenanthrene in which the carbon at position 10a is replaced by a nitrogen and which is substituted by an isobutyl group at position 2, an oxo group at position 3, and methoxy groups at positions 6 and 7.benzoquinolizine;
cyclic ketone;
tertiary amino compound
2h-benzo(a)quinolizin-2-ol, 2-ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-: Proposed catecholamine depletor.
lobeline(-)-lobeline : An optically active piperidine alkaloid having a 2-oxo-2-phenylethyl substituent at the 2-position and a 2-hydroxy-2-phenylethyl group at the 6-position.aromatic ketone;
piperidine alkaloid;
tertiary amine
nicotinic acetylcholine receptor agonist
dihydrotetrabenazinedihydrotetrabenazine: RN given refers to cpd without isomeric designationisoquinolines
lobeline
lobelanelobelane: structure in first source
mrk 560MRK 560: a gamma-secretase inhibitor; MRK-560 is the (cis)-isomer; structure in first source