clathrin-sculpted monoamine transport vesicle membrane

Definition

Target type: cellularcomponent

The lipid bilayer surrounding a clathrin-sculpted monoamine transport vesicle. [GOC:mg2]

The clathrin-sculpted monoamine transport vesicle membrane is a specialized cellular component involved in the regulated transport of monoamine neurotransmitters. It is a dynamic structure that undergoes a complex series of events during its formation, cargo loading, and fusion with the plasma membrane. The membrane is characterized by its association with clathrin, a protein that forms a lattice-like cage around the vesicle. This clathrin coat provides structural support and helps to drive vesicle budding from the donor compartment. The membrane also contains a variety of other proteins, including adaptor proteins, sorting signals, and transmembrane receptors, which are involved in the selective packaging of monoamine neurotransmitters into the vesicle lumen. Monoamine transporters, such as dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT), are embedded in the vesicle membrane. They play a crucial role in the uptake of monoamines from the cytoplasm into the vesicle lumen. The membrane also contains V-type ATPases, which are proton pumps that maintain the electrochemical gradient necessary for efficient monoamine transport. Once the vesicle is fully loaded with neurotransmitters, it detaches from the donor compartment and moves towards the plasma membrane for exocytosis. At the plasma membrane, the vesicle fuses with the cell surface, releasing its cargo of neurotransmitters into the synaptic cleft, where they can bind to postsynaptic receptors and initiate signaling.'
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Proteins (4)

Compounds (9)