Page last updated: 2024-10-24

chromatoid body

Definition

Target type: cellularcomponent

A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182). [PMID:17183363]

Proteins (2)

ProteinDefinitionTaxonomy
Serine/threonine-protein kinase SMG1A serine/threonine-protein kinase SMG1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96Q15]Homo sapiens (human)
Eukaryotic translation initiation factor 4EA eukaryotic translation initiation factor 4E that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06730]Homo sapiens (human)

Compounds (5)

CompoundDefinitionClassesRoles
cgp 60474substituted aniline
sirolimussirolimus : A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.

Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
antibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol
antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor
6-mercapto-7-methylguanosine6-mercapto-7-methylguanosine: structure given in first source
cgp 57380CGP 57380: inhibits the mitogen-activated protein kinase-interacting kinase Mnk1pyrazolopyrimidine
7-methyl-GTPguanosine 5'-phosphate