Target type: cellularcomponent
The lipid bilayer surrounding the platelet dense tubular network. [GOC:mah, PMID:1322202]
| Protein | Definition | Taxonomy |
|---|---|---|
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | A sarcoplasmic/endoplasmic reticulum calcium ATPase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q93084] | Homo sapiens (human) |
| Inositol 1,4,5-trisphosphate receptor type 1 | An inositol 1,4,5-trisphosphate receptor type 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14643] | Homo sapiens (human) |
| Inositol 1,4,5-trisphosphate receptor type 3 | An inositol 1,4,5-trisphosphate receptor type 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14573] | Homo sapiens (human) |
| Inositol 1,4,5-trisphosphate receptor type 2 | An inositol 1,4,5-trisphosphate receptor type 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14571] | Homo sapiens (human) |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | A sarcoplasmic/endoplasmic reticulum calcium ATPase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P16615] | Homo sapiens (human) |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | A sarcoplasmic/endoplasmic reticulum calcium ATPase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14983] | Homo sapiens (human) |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | A sarcoplasmic/endoplasmic reticulum calcium ATPase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q93084] | Homo sapiens (human) |
| Inositol 1,4,5-trisphosphate receptor type 1 | An inositol 1,4,5-trisphosphate receptor type 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14643] | Homo sapiens (human) |
| Inositol 1,4,5-trisphosphate receptor type 3 | An inositol 1,4,5-trisphosphate receptor type 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14573] | Homo sapiens (human) |
| Inositol 1,4,5-trisphosphate receptor type 2 | An inositol 1,4,5-trisphosphate receptor type 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14571] | Homo sapiens (human) |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | A sarcoplasmic/endoplasmic reticulum calcium ATPase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P16615] | Homo sapiens (human) |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | A sarcoplasmic/endoplasmic reticulum calcium ATPase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14983] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 2,5-di-tert-butylhydroquinone | 2,5-di-tert-butylbenzene-1,4-diol : A member of the class of hydroquinones that is benzene-1,4-diol substituted by tert-butyl groups at position 2 and 5. | hydroquinones | |
| chelerythrine | chelerythrine : A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae. | benzophenanthridine alkaloid; organic cation | antibacterial agent; antineoplastic agent; EC 2.7.11.13 (protein kinase C) inhibitor |
| paxilline | paxilline : An indole diterpene alkaloid with formula C27H33NO4 isolated from Penicillium paxilli. It is a potent inhibitor of large conductance Ca2(+)- and voltage-activated K(+) (BK)-type channels. paxilline: structure given in first source; RN given refers to (2R-(2alpha,4bbeta,6aalpha,12bbeta,12calpha,14abeta))-isomer | diterpene alkaloid; enone; organic heterohexacyclic compound; terpenoid indole alkaloid; tertiary alcohol | anticonvulsant; Aspergillus metabolite; EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor; genotoxin; geroprotector; mycotoxin; Penicillium metabolite; potassium channel blocker |
| inositol 1,4,5-trisphosphate | Inositol 1,4,5-Trisphosphate: Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin. | myo-inositol trisphosphate | mouse metabolite |
| thapsigargin | thapsigargin : An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations. Thapsigargin: A sesquiterpene lactone found in roots of THAPSIA. It inhibits SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. | butyrate ester; organic heterotricyclic compound; sesquiterpene lactone | calcium channel blocker; EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor |
| curcumin | curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa. Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes. | aromatic ether; beta-diketone; diarylheptanoid; enone; polyphenol | anti-inflammatory agent; antifungal agent; antineoplastic agent; biological pigment; contraceptive drug; dye; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; EC 1.8.1.9 (thioredoxin reductase) inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; flavouring agent; food colouring; geroprotector; hepatoprotective agent; immunomodulator; iron chelator; ligand; lipoxygenase inhibitor; metabolite; neuroprotective agent; nutraceutical; radical scavenger |
| biselyngbyaside | biselyngbyaside: antineoplastic from the marine cyanobacterium Lyngbya sp.; structure in first source | ||
| alpha-cyclopiazonic acid | alpha-cyclopiazonic acids |