Page last updated: 2024-10-24

positive regulation of cardiac muscle cell differentiation

Definition

Target type: biologicalprocess

Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. [GOC:BHF]

Positive regulation of cardiac muscle cell differentiation is a complex process involving intricate signaling pathways and gene expression regulation. It is essential for the development of a functional heart and involves the commitment of progenitor cells to the cardiomyocyte lineage, followed by their maturation and integration into the cardiac tissue. This process is tightly regulated by a multitude of factors, including:
- **Transcription factors:** Key players include GATA4, MEF2C, and NKX2.5, which activate genes crucial for cardiomyocyte differentiation.
- **Signaling pathways:** Signaling pathways like Wnt, Hedgehog, and Notch play critical roles in regulating the expression of these transcription factors and other differentiation-related genes.
- **Extracellular matrix:** Components of the extracellular matrix, such as laminin and collagen, provide structural support and signaling cues for cardiomyocyte differentiation.
- **Mechanical cues:** Forces exerted by the surrounding environment, such as stretch and pressure, influence cardiomyocyte differentiation through mechanotransduction pathways.
- **MicroRNAs:** Small non-coding RNA molecules called microRNAs can regulate gene expression and fine-tune cardiomyocyte differentiation.
This intricate interplay of molecular and cellular mechanisms ensures the proper differentiation of cardiac muscle cells, contributing to the formation of a healthy and functional heart.'
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Proteins (2)

ProteinDefinitionTaxonomy
Histone acetyltransferase KAT2AA histone acetyltransferase KAT2A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92830]Homo sapiens (human)
Protein Wnt-3aA protein Wnt-3a that is encoded in the genome of human. [PRO:DNx, UniProtKB:P56704]Homo sapiens (human)

Compounds (5)

CompoundDefinitionClassesRoles
3-furancarboxylic acid, tetrahydro-4-methylene-5-oxo-2-propyl-, (2r,3s)-rel-gamma-lactone
i-bet726
CCT251545CCT251545 : A chloropyridine that is 3-chloropyridine substituted by a 1-oxo-2,8-diazaspiro[4.5]decan-8-yl group and a 4-(1-methyl-1H-pyrazol-4-yl)phenyl group at positions 4 and 5, respectively. It is an orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM) and a potent and selective chemical probe for cyclin-dependent kinases CDK8 and CDK19.

CCT251545: a Wnt signaling inhibitor; structure in first source
azaspiro compound;
chloropyridine;
pyrazoles
antineoplastic agent;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor;
Wnt signalling inhibitor
xav939XAV939 : A thiopyranopyrimidine in which a 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine skeleton is substituted at C-4 by a hydroxy group and at C-2 by a para-(trifluoromethyl)phenyl group.

XAV939: selectively inhibits beta-catenin-mediated transcription; structure in first source
(trifluoromethyl)benzenes;
thiopyranopyrimidine
tankyrase inhibitor
nvp-tnks656