positive regulation of cardiac muscle cell differentiation
Definition
Target type: biologicalprocess
Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. [GOC:BHF]
Positive regulation of cardiac muscle cell differentiation is a complex process involving intricate signaling pathways and gene expression regulation. It is essential for the development of a functional heart and involves the commitment of progenitor cells to the cardiomyocyte lineage, followed by their maturation and integration into the cardiac tissue. This process is tightly regulated by a multitude of factors, including:
- **Transcription factors:** Key players include GATA4, MEF2C, and NKX2.5, which activate genes crucial for cardiomyocyte differentiation.
- **Signaling pathways:** Signaling pathways like Wnt, Hedgehog, and Notch play critical roles in regulating the expression of these transcription factors and other differentiation-related genes.
- **Extracellular matrix:** Components of the extracellular matrix, such as laminin and collagen, provide structural support and signaling cues for cardiomyocyte differentiation.
- **Mechanical cues:** Forces exerted by the surrounding environment, such as stretch and pressure, influence cardiomyocyte differentiation through mechanotransduction pathways.
- **MicroRNAs:** Small non-coding RNA molecules called microRNAs can regulate gene expression and fine-tune cardiomyocyte differentiation.
This intricate interplay of molecular and cellular mechanisms ensures the proper differentiation of cardiac muscle cells, contributing to the formation of a healthy and functional heart.'
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Proteins (2)
| Protein | Definition | Taxonomy |
|---|---|---|
| Histone acetyltransferase KAT2A | A histone acetyltransferase KAT2A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92830] | Homo sapiens (human) |
| Protein Wnt-3a | A protein Wnt-3a that is encoded in the genome of human. [PRO:DNx, UniProtKB:P56704] | Homo sapiens (human) |
Compounds (5)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 3-furancarboxylic acid, tetrahydro-4-methylene-5-oxo-2-propyl-, (2r,3s)-rel- | gamma-lactone | ||
| i-bet726 | |||
| CCT251545 | CCT251545 : A chloropyridine that is 3-chloropyridine substituted by a 1-oxo-2,8-diazaspiro[4.5]decan-8-yl group and a 4-(1-methyl-1H-pyrazol-4-yl)phenyl group at positions 4 and 5, respectively. It is an orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM) and a potent and selective chemical probe for cyclin-dependent kinases CDK8 and CDK19. CCT251545: a Wnt signaling inhibitor; structure in first source | azaspiro compound; chloropyridine; pyrazoles | antineoplastic agent; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor; Wnt signalling inhibitor |
| xav939 | XAV939 : A thiopyranopyrimidine in which a 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine skeleton is substituted at C-4 by a hydroxy group and at C-2 by a para-(trifluoromethyl)phenyl group. XAV939: selectively inhibits beta-catenin-mediated transcription; structure in first source | (trifluoromethyl)benzenes; thiopyranopyrimidine | tankyrase inhibitor |
| nvp-tnks656 |