L-serine import across plasma membrane

Definition

Target type: biologicalprocess

The directed movement of L-serine into a cell. [GO_REF:0000075, GOC:TermGenie, PMID:23895341]

L-serine import across the plasma membrane is a crucial process for cellular metabolism. L-serine, a non-essential amino acid, plays vital roles in various metabolic pathways, including protein synthesis, lipid biosynthesis, and one-carbon metabolism.

The import of L-serine into cells is primarily mediated by a family of membrane transporters known as the solute carrier family 6 (SLC6) transporters. These transporters are highly specific for L-serine and utilize a sodium-dependent cotransport mechanism.

The process begins with the binding of L-serine and sodium ions to the transporter protein on the extracellular side of the plasma membrane. This binding event triggers a conformational change in the transporter, allowing the movement of both L-serine and sodium ions across the membrane. The driving force for this transport is the electrochemical gradient of sodium ions, which is maintained by the sodium-potassium pump.

As L-serine and sodium ions move into the cell, the transporter returns to its original conformation, ready for another round of transport. The energy required for L-serine import is ultimately derived from the hydrolysis of ATP by the sodium-potassium pump.

The regulation of L-serine import is complex and involves multiple factors, including the availability of L-serine in the extracellular environment, the activity of the sodium-potassium pump, and the expression levels of the transporter proteins.

The import of L-serine is essential for maintaining cellular homeostasis and supporting various metabolic processes. Dysregulation of L-serine import has been implicated in several diseases, including cancer, neurodegenerative disorders, and metabolic disorders.'
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Proteins (1)

Compounds (8)