L-glutamine import across plasma membrane

Definition

Target type: biologicalprocess

The directed movement of L-glutamine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:23895341]

L-glutamine, a non-essential amino acid, is transported across the plasma membrane by a variety of membrane transporters. The most prominent system is the system N-type amino acid transporter, also known as SNAT2. SNAT2 is a sodium-dependent transporter, meaning it uses the electrochemical gradient of sodium ions to drive the uptake of L-glutamine. The transporter is a bidirectional transporter, meaning it can move L-glutamine in both directions across the membrane. The direction of L-glutamine transport is determined by the concentration gradient of L-glutamine across the membrane. In addition to SNAT2, other transporters such as LAT1 and ASCT2 can also transport L-glutamine, although their contribution to overall L-glutamine uptake is less than SNAT2. The transport of L-glutamine is essential for various cellular processes, including protein synthesis, energy production, and the synthesis of other amino acids. L-glutamine is the most abundant amino acid in the body, and its transport across the plasma membrane is essential for maintaining cellular homeostasis.'
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Proteins (1)

Compounds (8)