positive regulation of lymphangiogenesis

Definition

Target type: biologicalprocess

Any process that activates or increases the frequency, rate or extent of lymphangiogenesis. [GOC:dph, GOC:TermGenie, PMID:20133819]

Positive regulation of lymphangiogenesis is a complex biological process involving the growth and development of lymphatic vessels. Lymphatic vessels are essential for fluid homeostasis, immune surveillance, and lipid transport. Lymphangiogenesis is tightly regulated and involves a series of molecular events, including the activation of growth factors, the recruitment of endothelial cells, and the formation of new lymphatic vessels.

One of the key players in lymphangiogenesis is vascular endothelial growth factor-C (VEGF-C), a growth factor that specifically targets lymphatic endothelial cells. VEGF-C binds to its receptor, VEGFR-3, which is expressed on the surface of lymphatic endothelial cells. Binding of VEGF-C to VEGFR-3 triggers a signaling cascade that promotes cell proliferation, migration, and differentiation, ultimately leading to the formation of new lymphatic vessels.

In addition to VEGF-C, other growth factors, such as fibroblast growth factor-2 (FGF-2) and transforming growth factor-beta (TGF-β), have been implicated in lymphangiogenesis. These growth factors can act synergistically with VEGF-C to enhance lymphatic vessel growth.

The recruitment of lymphatic endothelial cells is another important step in lymphangiogenesis. Lymphatic endothelial cells are derived from a population of progenitor cells that reside in the bone marrow. These progenitor cells are mobilized to the site of lymphatic vessel formation, where they differentiate into mature lymphatic endothelial cells.

Once lymphatic endothelial cells are recruited to the site of lymphangiogenesis, they begin to form new lymphatic vessels. This process involves cell-cell interactions, as well as the secretion of extracellular matrix components, such as collagen and laminin. These components provide structural support for the developing lymphatic vessels.

Lymphangiogenesis is a tightly regulated process that is influenced by a variety of factors, including growth factors, cytokines, and hormones. Aberrant lymphangiogenesis can contribute to a number of diseases, including cancer, lymphedema, and inflammatory disorders. Understanding the molecular mechanisms underlying lymphangiogenesis is essential for developing novel therapeutic strategies for these diseases.'
"

Proteins (1)

Compounds (5)