L-ornithine import across plasma membrane

Definition

Target type: biologicalprocess

The directed movement of L-ornithine from outside of a cell, across the plasma membrane and into the cytosol. [GOC:krc, PMID:8195186]

L-ornithine transport across the plasma membrane is a complex process involving a specific carrier protein. This protein, known as an ornithine transporter, facilitates the movement of L-ornithine from the extracellular space into the cell. The process is typically driven by a concentration gradient, meaning L-ornithine moves from an area of higher concentration to an area of lower concentration. The transport can also be coupled to the movement of other ions, such as sodium or protons, creating an electrochemical gradient that drives the transport. In some cases, the transport may be active, requiring the expenditure of cellular energy to move L-ornithine against its concentration gradient. The specific mechanism of L-ornithine transport varies depending on the cell type and the transporter involved. For instance, some transporters may utilize a symport mechanism, where L-ornithine and another molecule (like sodium) are transported together, while others may use an antiport mechanism, where L-ornithine is transported in one direction while another molecule is transported in the opposite direction. L-ornithine transport plays a crucial role in various cellular processes, including protein synthesis, urea cycle, and polyamine biosynthesis. It is also involved in the regulation of intracellular L-ornithine levels, which are important for maintaining cellular function. Dysregulation of L-ornithine transport can lead to various metabolic disorders and disease states. For example, genetic mutations in ornithine transporter genes can cause hyperornithinemia, a rare genetic disorder characterized by elevated levels of L-ornithine in the blood and urine.'
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Proteins (1)

Compounds (2)