lysine biosynthetic process via diaminopimelate

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. [GOC:go_curators]

Lysine biosynthesis via diaminopimelate is a crucial metabolic pathway in bacteria, archaea, and some plants, which ultimately produces the essential amino acid lysine. This process diverges from the well-known lysine biosynthesis pathway in fungi and animals and utilizes diaminopimelate (DAP) as an intermediate. The pathway begins with the condensation of pyruvate and aspartate to form aspartate semialdehyde. This molecule is then converted to α-aminoadipate, which is further transformed into α-aminoadipate semialdehyde. This intermediate undergoes a series of steps, including a reductive amination with glutamate and a decarboxylation, resulting in the formation of L-lysine. However, in the diaminopimelate pathway, the α-aminoadipate semialdehyde molecule is not directly converted to L-lysine. Instead, it undergoes a key step where it is condensed with pyruvate to form tetrahydrodipicolinate. This molecule is then reduced to dihydrodipicolinate, which is further transformed through a series of steps involving dehydration and amination to ultimately yield L-diaminopimelate. DAP is a critical precursor to L-lysine. It is first decarboxylated to L-α-aminoadipate-δ-semialdehyde, which is then reduced to L-lysine by the enzyme diaminopimelate decarboxylase. The lysine biosynthetic pathway via diaminopimelate is a complex process involving multiple enzymatic steps and unique intermediates. It is a critical pathway in various organisms for the production of the essential amino acid lysine, which plays a key role in diverse biological processes, including protein synthesis, cell growth, and immune function.'
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Proteins (3)

Compounds (6)