polyamine catabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups. [ISBN:0198506732]

Polyamine catabolism is a crucial metabolic process responsible for the breakdown of polyamines, a group of small, positively charged organic molecules essential for cell growth, proliferation, and differentiation. Polyamine catabolic process begins with the oxidative deamination of polyamines by the enzyme diamine oxidase (DAO) or spermidine/spermine N1-acetyltransferase (SSAT). DAO primarily catalyzes the oxidative deamination of putrescine, spermidine, and spermine, producing hydrogen peroxide and the corresponding aldehydes, such as 4-aminobutanal from putrescine. SSAT, on the other hand, acetylates spermidine and spermine, forming N1-acetylspermidine and N1-acetylspermine, respectively. These acetylated derivatives are then substrates for the enzyme acetylpolyamine oxidase (APAO), which oxidizes them to produce 1,3-diaminopropane and H2O2. The final step in polyamine catabolism is the conversion of 1,3-diaminopropane to γ-aminobutyraldehyde by diamine oxidase, which can be further metabolized to γ-aminobutyric acid (GABA) or other metabolites. The polyamine catabolic pathway plays a critical role in regulating polyamine levels within cells, ensuring proper cellular function. Dysregulation of this pathway has been implicated in various disease states, including cancer, inflammation, and neurodegenerative disorders. '
"

Proteins (1)

Compounds (3)