Target type: biologicalprocess
The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. [GOC:curators]
| Protein | Definition | Taxonomy |
|---|---|---|
| S-adenosylmethionine decarboxylase proenzyme | A SAM decarboxylase proenzyme that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17707] | Homo sapiens (human) |
| Spermine synthase | A spermine synthase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P52788] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| putrescine | alkane-alpha,omega-diamine | antioxidant; fundamental metabolite | |
| s-adenosyl-3-thio-1,8-diaminooctane | S-adenosyl-3-thio-1,8-diaminooctane: structure given in first source | ||
| s-adenosyl-1,12-diamino-3-thio-9-azadodecane | S-adenosyl-1,12-diamino-3-thio-9-azadodecane: structure given in first source | ||
| mitoguazone | mitoguazone : A hydrazone obtained by formal condensation of the two carbonyl groups of methylglyoxal with the primary amino groups of two molecules of aminoguanidine. Mitoguazone: Antineoplastic agent effective against myelogenous leukemia in experimental animals. Also acts as an inhibitor of animal S-adenosylmethionine decarboxylase. | guanidines; hydrazone | antineoplastic agent; apoptosis inducer; EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor |