Page last updated: 2024-10-24

spermine biosynthetic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. [GOC:curators]

Proteins (2)

ProteinDefinitionTaxonomy
S-adenosylmethionine decarboxylase proenzymeA SAM decarboxylase proenzyme that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17707]Homo sapiens (human)
Spermine synthaseA spermine synthase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P52788]Homo sapiens (human)

Compounds (4)

CompoundDefinitionClassesRoles
putrescinealkane-alpha,omega-diamineantioxidant;
fundamental metabolite
s-adenosyl-3-thio-1,8-diaminooctaneS-adenosyl-3-thio-1,8-diaminooctane: structure given in first source
s-adenosyl-1,12-diamino-3-thio-9-azadodecaneS-adenosyl-1,12-diamino-3-thio-9-azadodecane: structure given in first source
mitoguazonemitoguazone : A hydrazone obtained by formal condensation of the two carbonyl groups of methylglyoxal with the primary amino groups of two molecules of aminoguanidine.

Mitoguazone: Antineoplastic agent effective against myelogenous leukemia in experimental animals. Also acts as an inhibitor of animal S-adenosylmethionine decarboxylase.
guanidines;
hydrazone
antineoplastic agent;
apoptosis inducer;
EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor