Page last updated: 2024-10-24

positive regulation of acute inflammatory response to non-antigenic stimulus

Definition

Target type: biologicalprocess

Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus. [GOC:add]

Positive regulation of acute inflammatory response to non-antigenic stimulus is a complex biological process involving a cascade of events initiated by the recognition of non-antigenic stimuli, such as physical injury, mechanical stress, or certain chemicals. These stimuli trigger the release of pro-inflammatory mediators, including cytokines, chemokines, and other signaling molecules, by various cell types, such as macrophages, neutrophils, and mast cells. These mediators activate and recruit immune cells to the site of injury or stress, initiating an inflammatory response characterized by vasodilation, increased vascular permeability, and the influx of immune cells. The influx of neutrophils and macrophages leads to phagocytosis and clearance of damaged cells and debris, while the release of cytokines promotes tissue repair and restoration of homeostasis. The overall process is tightly regulated to ensure an appropriate and balanced inflammatory response, preventing excessive inflammation and potential tissue damage. Notably, the specific molecular mechanisms and cellular players involved in this process can vary depending on the specific non-antigenic stimulus and the tissue context.'
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Proteins (2)

ProteinDefinitionTaxonomy
Free fatty acid receptor 2A free fatty acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15552]Homo sapiens (human)
Free fatty acid receptor 3A free fatty acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14843]Homo sapiens (human)

Compounds (7)

CompoundDefinitionClassesRoles
acetic acidacetic acid : A simple monocarboxylic acid containing two carbons.

Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
monocarboxylic acidantimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent
butyric acidbutyrate : A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group.

butyric acid : A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.

Butyric Acid: A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.
fatty acid 4:0;
straight-chain saturated fatty acid
human urinary metabolite;
Mycoplasma genitalium metabolite
propionic acidpropionic acid : A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group.saturated fatty acid;
short-chain fatty acid
antifungal drug
2-(4-chlorophenyl)-3-methyl-N-(2-thiazolyl)butanamideacetamides
sodium butyrateorganic sodium saltEC 3.5.1.98 (histone deacetylase) inhibitor;
geroprotector
gw9508GW9508: structure in first sourcearomatic amine
4-(((r)-1-(benzo(b)thiophene-3-carbonyl)-2-methyl-azetidine-2-carbonyl)-(3-chloro-benzyl)-amino)-butyric acid4-(((R)-1-(benzo(b)thiophene-3-carbonyl)-2-methyl-azetidine-2-carbonyl)-(3-chloro-benzyl)-amino)-butyric acid: structure in first source